摘要
目的探讨Graves病、Graves眼病患者促甲状腺受体抗体(TRAb)测定的临床意义。方法用放射免疫法测定单纯Graves病组(A组,83例)和Graves眼病组(B组,73例)患者血清TRAb水平,并行Graves眼病临床活动性评分(CAS)和以NOSPECS分级判断眼病严重度。结果血清TRAb水平和眼病的活动度与严重度呈正相关,且中重度Graves眼病者TRAb水平显著高于轻度Graves眼病者(P<0.05)。结论血清TRAb值的显著增高可考虑为预测Graves眼病发展及指导治疗的指标之一。
Objective To investigate the significance of detecting serum thyrotropin receptor antibodies（TRAb） in patients with Graves disease or Graves ophthalmopathy.Methods Serum TRAb was measured using radioimmunoassay in 83 patients with Graves disease（group A）,73 patients with Graves ophthalmopathy（group B）.Patients with Graves ophthalmopathy were assessed using clinical activity score（CAS） and the severity of Graves ophthalmopathy was evaluated using NOSPECS Grade.Results Serum concentration of TRAb was positively correlated with the activity and severity of Graves ophthalmopathy,which was higher in patients with middle and serious Graves ophthalmopathy than that in those with slight Graves ophthalmopathy（P〈0.05）.ConclusionSignificant increase of serum TRAb may be taken as one of the markers to predict the development and guide the treatment in the patients with Graves ophthalmopathy.
出处
《江苏医药》
CAS
CSCD
北大核心
2011年第15期1777-1779,共3页
Jiangsu Medical Journal
