摘要
目的通过与非巨大性甲状腺肿组的对比,探讨131I治疗巨大性甲状腺肿性Graves甲亢的临床疗效。方法选取经过131I治疗的甲状腺质量>70 g的甲亢患者128例作为研究组,同期经过131I治疗的甲状腺质量<70 g的甲亢患者318例作为对照组,对比131I治疗后两组患者一次治愈率、总治愈率及甲状腺功能减退发生情况。结果 131I治疗巨大甲状腺肿性Graves甲亢的总治愈率95.3%,一次治愈率46.9%,早发甲减发生率4.7%;对照组总治愈率90.9%,一次治愈率65.7%,早发甲减发生率9.1%。两组一次治愈率有统计学差异(P=0.000);两组总治愈率、早发甲减发生率无统计学差异(P=0.115)。结论 131I治疗巨大甲状腺肿性Graves甲亢安全有效,无一例发生气管压迫、喉头水肿、甲亢危象等不良反应,总治愈率与早发甲减的发生率与非巨大性甲状腺肿性Graves甲亢相近。
Objective To evaluate the feasibility,efficacy and safety of radioiondine therapy in the treatment of Graves＇ hyperthyroidism with large goiter.Methods A total of 128 patients with Graves;hyperthyroidism with large goiter（thyroid weight70 g） as the study group were treated with radioiondine,using 318 concurrent patients with Graves disease with a smaller goiter（thyroid weight70 g） as the control group.The cure rate following a single-session treatment,the total cure rate and the incidence of hypothyroidism were compared between the two groups.Results In the large goiter group,the total cure rate was 95.3%,and the cure rate following a single-session treatment was 46.9%,with the incidence of hypothyroidism of 4.7%,as compared with 90.9%,65.7%,and 9.1% in the control group,respectively.A significant difference was noted in the cure rate following a single-session treatment（P=0.000）,but not in the total cure rate or the incidence of early-onset hypothyroidism（P=0.115） between the two groups.No tracheal compression,laryngeal edema,or hyperthyroidism crisis occurred in the large goiter group after the treatment.Conclusion Radioiondine is safe and effective for treatment of Graves＇ hyperthyroidism with large goiter,and results in a total cure rate and incidence of early-onset hypothyroidism similar to those in patients with goiters of a smaller size.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2011年第8期1464-1466,共3页
Journal of Southern Medical University
