摘要
目的:观察蛭萸汤治疗肾虚血瘀型糖尿病性周围神经病变(DPN)的临床疗效。方法:将120例肾虚血瘀型DPN患者随机分成中医治疗组60例、西医对照组30例和中医对照组30例。所有患者均给予糖尿病基础治疗,中医治疗组服用蛭萸汤,西医对照组口服弥可保片、培达,中医对照组服用中汇糖脉康冲剂,治疗周期均为3个月。观察并比较三组患者的临床疗效、主要症状体征、神经传导速度及纤维蛋白原(FB)、胆固醇(TC)、三酰甘油(TG)、血糖、糖化血红蛋白等指标。结果:①中医治疗组中医证候和神经传导速度改善的总有效率分别为80.0%和78.3%,西医对照组和中医对照组证候与神经传导改善总有效率均分别为53.3%和50.0%;中医治疗组的中医证候和神经传导速度疗效均显著优于中、西医对照组(P<0.01)。②治疗后,三组患者的症状和体征总积分较治疗前均显著下降(P<0.01);中医治疗组与中、西医对照组比较,其总积分降低更加显著(P<0.01)。③治疗后,中医治疗组FB、TG水平均明显下降(P<0.05,P<0.01),西医对照组FB水平亦明显降低(P<0.05),且中医治疗组的FB水平较中医对照组亦显著降低(P<0.05)。④治疗后,中医治疗组患者的腓总和正中神经MCV、SCV均显著提高(P<0.01),西医对照组患者的腓总神经和正中神经SCV亦显著提高(P<0.05);中医治疗组与中、西医对照组比较,其腓总神经和正中神经的MCV、SCV均显著提高(P<0.05)。结论:蛭萸汤能明显改善肾虚血瘀型DPN患者的临床症状,提高其外周运动和感觉神经的传导速度,延缓DPN的进展。
Objective： To observe the clinical effects of ＂Zhiyu Decoction＂ in treating diabetic peripheral neuropathy（DPN） of kidney-deficiency and blood-stasis.Methods： 120 patients with DPN of kidney-deficiency and blood-stasis were randomly divided into traditional Chinese medical（TCM） treatment group（n=60）,western medical control group（n=30） and TCM control group（n=30）.All the patients were treated by diabetic foundational treatment,besides the TCM treatment group was treated by ＂Zhiyu Decoction＂,the western medical control group was treated by Mecobalamine and Pletaal,and the TCM control group was treated by ＂Zhonghui Tangmaikang Granule＂,with the course of three months.The clinical effects,main symptoms and signs,nerve conduction velocity,fibrinogen（FB）,cholesterol（TC）,triglycerides（TG）,blood glucose and HbA1c were observed and compared.Results： ①The total effective rates of the improvement of clinical symptoms and nerve conduction velocity in TCM treatment group were 80.0% and 78.3% respectively,and the total effective rates in both western medical control group and TCM control group were 53.3% and 50.0% respectively.The clinical effect of TCM treatment group was better than that of western medical control group and TCM control group（P0.01）.②After treatment,the total scores of symptoms and signs in three groups significantly decreased compared with before treatment（P0.01）;the total scores of TCM treatment group were lower than those of TCM control group and western medical control group（P0.01）.③After treatment,the levels of FB and TG in TCM treatment group significantly decreased（P0.05,P0.01）,the level of FB in western medical control group also obviously decreased（P0.05）,and the level of FB of TCM treatment group was lower than that of TCM control group（P0.05）.④After treatment,the motor nerve conduction velocity（MCV）and sensory nerve conduction velocity（SCV）of common peroneal nerve and median nerve in TCM treatment group obviously increased（P0.01）,the SCV of common peroneal nerve and median nerve in western medical control group also obviously increased（P0.05）,and the MCV and SCV of common peroneal nerve and median nerve of TCM treatment group were higher than those of western medical control group and TCM control group（P0.05）.Conclusion： ＂Zhiyu Decoction＂ can improve the clinical symptoms of patients with DPN of kidney-deficiency and blood-stasis,increase the peripheral sensory nerve and motor nerve conduction velocity,and delay the progress of DPN.
出处
《上海中医药大学学报》
CAS
2011年第4期45-50,共6页
Academic Journal of Shanghai University of Traditional Chinese Medicine
基金
上海市科委科研基金资助项目(603.31.21)
关键词
糖尿病性周围神经病变
蛭萸汤
温肾活血
Diabetic peripheral neuropathy
＂Zhiyu Decoction＂
warming kidney and activating blood
