短期胰岛素泵强化治疗对2型糖尿病早期肾病尿蛋白的影响被引量：2

The Influence of Short-term Insulin Pump in Treatment of Urinary Albumin with Earlier Type 2 Diabetic Nephropathy

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摘要目的观察短期胰岛素泵强化治疗对早期糖尿病肾病（DN）尿蛋白的影响。方法将60例早期DN患者随机分为常规2次皮下注射诺和灵30R（DNl）组和胰岛素泵持续皮下输注门冬胰岛素（DN2）组，2周后观察两组治疗前后空腹血糖（FBG）、餐后血糖（2hPG）、血糖变异系数、尿微量白蛋白排泄率（UAER）、尿β2微球蛋白（β2-MG）及糖化血红蛋白（HbAIC）的变化。结果与常规2次皮下注射相比，短期胰岛素泵强化治疗改善了血糖控制，显著减少低血糖发生率，减小血糖变异系数（均P〈0.01）。同时UAER、β2-MG、C反应蛋白（CRP）等也均较DNI组明显下降（均P〈0，05）。结论胰岛素泵强化治疗能进一步降低早期DN患者UAER，延缓糖尿病肾病的进展，其机制可能与控制血糖的波动与抑制炎症因子释放有关。 Objective To study the impact of short-term insulin pump treatment on urinary protein in patients with type 2 diabetic nephropathy, and to evaluate the protect role of insulin pump treatment. Methods 60 type 2 diabetes mellitus patients with microalbuminuria were divided into two subgroups：normal treatment group（DN1） and insulin pump short-term intensive therapy group（DN2）.The fasting blood glucose（FBG）,postprandial blood glucose（2hPG）,coefficient of variation of blood glucose,HbA1C,urinary albumin excretion rate（UAER）, β2- MG,C-reactive protein（CRP） were detected. Results Compared with subcutaneous insulin injection, short-term intensive therapy of diabetic hyperglycemia with insulin pump improved blood glucose control,lowered the rates of hypoglycemia, diminished the coefficient of variation of blood glucose（P〈0.01）,UAER, β2-MG as well as CRP decreased dramatically after therapy in DN2 group（P〈0.05）. Conclusion The short-term intensive insulin treatment can reduced the early DN UAER,prevent and delay the development of diabetic nephropathy through the activity of anti-inflammation and reduction of fluctuation of the blood glucose.

作者方晨董吉祥胡吉谢莹马志敏

机构地区苏州大学附属第二医院内分泌科

出处《中国血液流变学杂志》 CAS 2011年第2期270-272,301,共4页 Chinese Journal of Hemorheology

关键词胰岛素强化治疗糖尿病肾病 C反应蛋白血糖变异系数 insulin intensive therapy diabetic nephropathy CRP coefficient of variation of blood glucose

分类号 R587.2 [医药卫生—内分泌]

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