摘要
目的探讨甲状腺髓样癌的临床病理特征。方法对16例经免疫组织化学证实为甲状腺髓样癌病例的临床、病理、免疫组织化学染色特征进行回顾性分析。结果甲状腺髓样癌多表现为结节状肿块,镜下形态表现复杂多样,癌样、肉瘤样均可,背景中常有淀粉样物质沉积。免疫组织化学:Ckpan(+)7例(43.75%),EMA(+)6例(37.5%),Vim(+)1例(6.25%),TG(-)16例(100.0%),CT(+)15例(93.75%),Syn(+)9例(56.25%),CgA(+)7例(43.75%),CEA(+)5例(31.25%),刚果红染色(+)14例(87.5%)。结论甲状腺髓样癌是一种形态多样化并伴有神经内分泌特征的侵袭性恶性肿瘤,其诊断依赖于组织形态及免疫组织化学染色特征。
Objective To investigate the clinicopathological features of medullary thyroid carcinoma.Methods The clinical,pathological and immunohistochemical characteristics of 16 cases of immunohistochemically proven medullary thyroid carcinoma were retrospectively analyzed.ResultsMedullary thyroid carcinoma had cancer like and sarcomatoid features,with the appearance of nodular mass and amyloid deposition.Of the 16 cases,immunohistochemistry showed Ckpan（＋）in 7（43.75%）,EMA（＋） in 6（37.5%）,Vim（＋） in 1（6.25%）,TG（-）in 16（100.0%）,CT（＋） in 15（93.75%）,Syn（＋）in 9（56.25%）,CgA（＋）in 7（43.75%）,CEA（＋）in 5（31.25%）,and Congored staining（＋）in 14（87.5%）.Conclusion Medullary thyroid carcinoma is a malignant tumor with morphological diversity and neuroendocrine characters,and its diagnosis depends on morphology and immunohistochemistry.
出处
《南昌大学学报（医学版）》
CAS
2011年第5期48-50,F0003,共4页
Journal of Nanchang University：Medical Sciences
关键词
甲状腺髓样癌
临床病理
诊断
medullary thyroid carcinoma
clinicopathology
diagnostic
