摘要
目的：运用meta分析法评价依达拉奉对体外循环心脏手术患者心肌缺血再灌注损伤（IRI）的疗效。方法：运用Cochrane系统评价的方法,检索Pubmed、Highwire Press、EMBASE、中国知网、万方科技文献数据库和中国生物医学文献数据库的文献及其参考文献,检索年限为2001年4月至2010年7月。筛选所有依达拉奉防治体外循环心脏手术患者心肌IRI的随机对照试验（RCT）。应用RevMan5.0分析。结果：共纳入6个RCT,方法学质量评价为B级。与对照组相比,依达拉奉组动脉开放后心脏自动复跳率显著增加（RR=1.54,95%CI=1.05~2.25,P=0.03）,术后24h血清SOD水平恢复较快（95%CI=0.47~1.18,SMD=0.82,P〈0.001）,动脉开放后2h血浆丙二醛（MDA）水平、动脉开放后6h和24h血清肌酸激酶同工酶（CK-MB）水平、心肌肌钙蛋白I（cTnI）水平及血浆MDA水平显著降低（P〈0.05）。结论：依达拉奉对心肌IRI具有一定的改善作用。
Aim：To assess the effectiveness of edaravone for treatment against ischemic-reperfusion injury（IRI）in patients undergoing cardic operation with cardiopulmonary by-pass.Methods：The related articles were searched,Pubmed,Highwire Press,EMBASE,WAN FANG DATA,CNKI and China Biological Medcine Database from Apr.2001 to Jul.2010.The Revman 5.0 software was used for the meta analysis.Results：A total of 6 RCT（n=202）were identified.The level of methodology was classified as B.Compared with the control group,in edravone group,there are significant difference in the spontaneous return rates of hearts after aorta declamping was higher（RR=1.54,95% CI=1.05~2.25,P=0.03）;and also in plasma concentration of MDA（at 2 h,6 h and 24 h after aorta declamping）,serum concentation of SOD（24 h after surgery operation 95%CI=0.47~1.18,SMD=0.82,P0.001）,CK-MB and cTnI（at 6 h and 24 h after aorta declamping）.Conclusion：Edaravone may have some protective effect for the treatment against ischemic-reperfusion injury in patients undergoing cardiac operation with cardiopulmonary by-pass.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2011年第4期604-608,共5页
Journal of Zhengzhou University(Medical Sciences)
关键词
依达拉奉
心肌缺血再灌注损伤
META分析
体外循环心脏手术
edravone
cardic ischemic-reperfusion injury
meta-analysis
cardic operation with cardiopulmonary by-pass
