摘要
目的:观察活血散瘀颗粒的活血化淤作用。方法:将Wistar大鼠随机分成6组:对照组、急性血瘀模型组、活血散瘀颗粒高、中、低剂量组(16,8,4 g.kg-1)和复方丹参片组(5 g.kg-1)。ig给药,每日1次,连续9 d。d 9时,sc肾上腺素10μg.kg-1,2 h后置0～4℃水中游泳5 min,2 h后,sc肾上腺素1次(10μg.kg-1),制造急性血瘀模型,测定各组给药9 d后对高切黏度、低切黏度、红细胞压积、血浆黏度及对血栓形成的影响;用肾上腺素制造大鼠肠系膜急性微循环障碍模型,观察活血散瘀颗粒对循环障碍的改善作用。结果:活血散瘀颗粒高剂量组和模型组比较,大鼠全血高、低切、血浆黏度和红细胞积压显著降低(P<0.05);血栓的长度、湿重、干重显著减少,凝血时间显著延长(P<0.05);可显著抑制肾上腺素引起的大鼠肠系膜微循环细动脉管径缩小、流速减慢、毛细血管开放量减少,并改善这些现象(P<0.05)。结论:活血散瘀颗粒可改善血液流变性及微循环障碍。
Objective：To observe promoting blood circulation by removing blood stasis of Huoxue Sanyu granule.Method：Sixty Wistar rats（n=10/group） were randomly divided into six group,the normal goup,the model group,the Fufang Danshen Tablets group,high Huoxue Sanyu granule group（16 g·kg-1）,middle Huoxue Sanyu granule group（8 g·kg-1） and low Huoxue Sanyu granule group（4 g·kg-1）.The trement groups were orally administered once per day for 9 d separately,whereas the normal and model group were orally administered with distilled water.Except norml rats,all the other rats were injected subcutaneously adrenalin 10 μg·kg-1,swam in icy water 5 min after 2 h the acute blood stasis rat models were made,and these rats were injected subcutaneously adrenalin 10 μg·kg-1 again after 2 h.The indexes on hemorheology after given drugs for nine days were measured order to investigate the influences of Huoxue Sanyu granule;mesenteric microcirculatory disturbance rat models were established with adalin in order to observe the effects of this drug.Result：Huoxue Sanyu granule could decrease rats blood viscosity,plasma viscosity,and relieve viscosity and coagulating condition of blood stasis rats blood,so it inhibited thrombosis;it could also inhibit the caliber decreasing of thin artery,the slowing of blood flow,the reducing of open capillaries and chang of fluid condition and improve these phenomena.Conclusion：Huoxue Sanyu granule may improve blood stasis rats hemorheology and microcirculatory disturbance.
出处
《中国实验方剂学杂志》
CAS
北大核心
2011年第16期191-194,共4页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
活血散瘀颗粒
血液流变性
微循环障碍
Huoxue Sanyu granule
hemorheology
microcirculatory disturbanc
