摘要
目的制备磺胺嘧啶银壳聚糖-海藻酸钠微球,并考察其体外释放度。方法采用乳化-交联法制备磺胺嘧啶银壳聚糖-海藻酸钠微球,研究微球的粒径、形态及体外释药情况。结果微球外观圆整,平均粒径38.2μm,体外5 h释药完全。结论磺胺嘧啶银微球制备方法简单易行,体外释药迅速。
Objective To prepare the chitosan-alginate sodium microspheres loaded with silver sulfadiazine and study their release characteristics. Methods The emulsion cross-linking technique was applied to produce the microspheres, and the diameter, morphology, and in vitro release behavior of which were studied. Results The appearance of microspheres was round and intact, the average diameter of which was 38.2 tzm, and the 5 h in vitro drug release was completely. Conclusion The process of preparing microspheres is simple and easy, and the drug release is quick, which deserving further research as the wound protective materials.
出处
《医药导报》
CAS
2011年第8期1072-1075,共4页
Herald of Medicine
关键词
磺胺嘧啶银
乳化-交联
壳聚糖-海藻酸钠微球
释放度
Silver sulfadiazine
Emulsion cross-linking
Chitosan-alginate sodium microspheres
Cumulative release rate
