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N端脑利钠肽前体在舒张性心力衰竭中的应用研究 被引量:8

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摘要 目的分析舒张性心力衰竭患者血浆N端脑利钠肽前体(NT-proBNP)水平变化的意义。方法将58例舒张性心力衰竭患者设为心力衰竭组,其中Ⅲ级组11例,Ⅳ级组47例,分别于就诊次日空腹和心功能改善至Ⅰ~Ⅱ级后采血,采用免疫荧光法测定血浆NT-proBNP。选取20例心功能正常的入院检查者为对照组。结果舒张性心力衰竭组NT-proBNP较对照组显著升高(P<0.01),且随心力衰竭程度加重而升高(P<0.01);舒张性心力衰竭组随着心功能的改善NT-proBNP水平明显下降,与治疗前比较差异有统计学意义(P<0.01)。结论舒张性心力衰竭时NT-proBNP升高,且随心功能损害加剧而升高明显,治疗后明显降低,提示NT-proBNP是可反映舒张性心力衰竭病情变化的指标,可用于舒张性心力衰竭患者的诊断及疗效观测。
作者 葛璘 陈湘
机构地区 北京航天总医院
出处 《实用心脑肺血管病杂志》 2011年第9期1487-1488,共2页 Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
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参考文献5

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二级参考文献9

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二级引证文献60

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