摘要
小鼠脑室埋管注射０．１２５％ ，０．２５％ 和０．５％ ＡｌＣｌ３，每只２ μＬ，每日１ 次，连续５ ｄ，末次注射后２０ ｄ 小鼠在跳台法和避暗法实验中潜伏期明显缩短，错误数明显增多． 大脑皮层及海马脑区铝含量明显增加， 与被动回避性条件反应的潜伏期和错误数存在显著相关关系， 脑干铝含量与小鼠行为变化无明显关系． 病理检查发现海马脑区出现神经元肿胀， 神经原纤维排列紊乱， 融合， 神经纤维缠结． 结果表明， 小鼠脑室埋管多次注射ＡｌＣｌ３ 可引起小鼠学习记忆功能障碍及脑组织， 特别是海马脑区出现病理损害．
The effect of intracerebroventricular(icv) injections of AlCl 3 on the mouse function of learning and memory was investigated. The mice were given 0.125%, 0.25% and 0.5% AlCl 3 2 μL per mouse, respectively, once a day for 5 d. The passive avoidance condition responses (step down and step through tests) were examined on d 20 after the last injection. The number of errors was increased and the latency shortened significantly in a dose dependent manner. The level of aluminum in the hippocampus and cortex regions in three AlCl 3 groups was obviously increased, which was related with the number of errors and the latency in the passive avoidance condition responses. In the pathological examination, some focal necroses, fused, disordered and thickened neurofibrilla and a few of neurofibrillary tangles were found in the hippocampal section of the mice from all AlCl 3 groups. The degree of pathological changes seemed to be related to the dose of AlCl 3. The data suggest that icv injections of AlCl 3 induces deficits of learning and memory, and the brain damage including the formation of neurofibrillary tangle by the accumulation of aluminum.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
1999年第4期260-263,共4页
Chinese Journal of Pharmacology and Toxicology
基金
美国中华医学基金会资助
关键词
学习
记忆
行为
氯化铝
铝毒性
aluminum
learning
memory
behavior, animal
