摘要
目的 :探讨白细胞介素 1β(interleukin - 1β ,IL - 1β)和肿瘤坏死因子α(tumornecrosisfactorα ,TNFα)对牙周组织的作用。方法 :将IL - 1β、TNFα注入到兔的牙周组织 ,以生理盐水为对照 ,不同时期取材做组织学观察和评价。 结果 :实验组 15天后牙龈组织血管扩张充血 ,牙槽骨改建活跃 ,有大量的骨吸收陷窝及破骨细胞 ,并有新骨形成和破骨细胞出现 ;30天后仅表现为大量的骨陷窝及破骨细胞 ,无成骨现象 ,且以联合应用IL - 1β、TNFα组最显著。 结论 :IL - 1β、TNFα均能引起牙龈炎症反应、附着上皮和牙槽骨的破坏 ,提示IL - 1β、TNFα在牙周组织疾病中有作用。
Objective:To investigate the pathopoiesis of IL-1β and TNF α on peiodontium.Methods:IL-1β、TNF α were injected into the periodontium of the rabbits,0.9% NS as a control group.At different periods after injection,the rabbits were sacrificed and the tissues were observed by histology. Results: In the early stage(15 days),the gingival tissues of experimental group showed vessel dilatation and hyperaemic.The reconstruction of the alveolar bone was active.Many absorbing lacna,osteoclast,some new bone and osteoblast can be seen.In the late stage(30 days),only the absorbing lacuna and osteoclast can be seen ,without the new bone formation.This phenomenon was most significant in the IL-1β and TNF α union group. Conclusions: Both IL-1β and TNF α can induce the inflamation of the gingivae and lead to the loss of the conjunction epithelium and the alveolar bone.This study shows that IL-1β and TNF α play a role in the periodontal disease.
出处
《口腔医学纵横》
CSCD
1999年第4期207-209,共3页
Journal of Comprehensive Stomatology
