摘要
p75神经营养因子受体属于神经营养因子的受体之一。越来越多的研究表明,p75NTR在心血管系统自主神经中发挥重要的作用,不仅促进交感神经的生长发育,还调节心脏神经递质的释放。p75NTR还抑制新生血管形成,具有一定的抗血管生成作用,且介导平滑肌细胞凋亡,加重血管粥样硬化损伤。p75NTR这些特性表明其抑制剂存在重要的治疗潜能,或许能够改善缺血所致的损伤,如冠心病、急性心肌梗死、周围血管病变等。
p75 neurotrophin receptor（p75NTR） is one of the neurotrophins receptors.Many studies have indicated that p75NTR plays an important role in the cardiovascular autonomic nervous system,such as promoting growth and development of sympathetic nerve,regulating cardiac neurotransmitter release.P75NTR have showed the strong anti-neovascularization effect in a mouse model of limb ischemia,so-called anti-angiogenic action.It was demonstrated that p75NTR was an inducer of smooth muscle cell apoptosis in atherosclerotic lesions.These suggest the therapeutic potential of p75NTR inhibition to combat ischemia-induced damage,such as coronary heart disease,acute myocardial infarction,peripheral vascular disease and so on.
出处
《中华老年多器官疾病杂志》
2011年第3期286-288,共3页
Chinese Journal of Multiple Organ Diseases in the Elderly
基金
国家自然基金(30770901)~~
