摘要
目的评估谷氨酰胺（glutamine，Gin）预防早产儿坏死性小肠结肠炎（necrotizing enterocolits，NEC）的临床疗效。方法将我科2007年10月至2010年3月收治的2717例早产儿分为Gin预防组（1389例）和非Gin预防组（1328例），观察两组患儿NEC的发病率。结果Gin预防组与非Gin预防组患儿在性别，胎龄，出生体质量，有无窒息史，是否合并肺炎、败血症、脑出血等方面比较，差异无统计学意义（P〉0．05）。Gin预防组1389例患儿中35例诊断为NEC，发病率为2．52％；非Gin预防组1328例患儿中68例诊断为NEC，发病率为5．12％，两组患儿发病率比较差异有统计学意义（x2=12．590，P〈0．01）。结论预防性应用Gin能降低早产儿NEC的发病率。
Objective To assess the role of glutamine in the prevention of necrotiziting enterocolitis （NEC） in preterm infants. Methods Two thousand seven hundred and seventeen preterm infants hospitalized in our NICU from Oct 2007 to Mar 2010 were assigned in either receiving prophylactic use of glutamine （ prevention group, n = 1 389 ） or without glutamine supplementation（ control group, n = 1 328 ）. The incidence of NEC was compared between the two groups. Results There were no significant differences in sex, gestation age, birth weight, neonatal asphyxia, pneumonia, septicemia and cerebral hemorrhage between the two groups （P 〉 0. 05）. Sixty-eight infants occurred NEC in the control group（5.12% ） ,but only 35 infants occurred NEC in the prevention group（2. 52% ） （x2 = 12. 590, P 〈 0.01 ）. Conclusion The prophylactic use of glutamine may reduce the incidence of NEC in preterm infants.
出处
《中国小儿急救医学》
CAS
2011年第4期327-328,共2页
Chinese Pediatric Emergency Medicine
关键词
谷氨酰胺
坏死性小肠结肠炎
早产儿
Glutamine
Necrotiziting enterocolitis
Preterm infants
