摘要
目的探讨高频雾化吸入3%高渗盐水和沙丁胺醇治疗慢性阻塞性肺疾病(COPD)的临床效果和安全性。方法将71例COPD患者随机分为两组,实验组36例,3%高渗盐水4 mL及沙丁胺醇5 mg高频雾化吸入;对照组35例,0.9%盐水4mL及沙丁胺醇5 mg高频雾化吸入,每日3次,直至症状、体征明显缓解。结果实验组喘息症状明显缓解平均时间为(2.6±0.7)d,而对照组为(4.3±1.1)d;实验组咯痰症状明显缓解平均时间为(5.1±1.5)d,而对照组为(6.9±2.0)d;实验组肺部湿啰音消失平均时间为(7.0±0.8)d,而对照组为(9.2±0.9)d;实验组的平均住院时间为(14.3±2.5)d,而对照组为(19.0±3.3)d,住院治疗期间无明显不良反应出现。结论雾化吸入3%高渗盐水是治疗COPD安全有效的手段。
Objective To study the efficacy of nebulized 3 % hypertonic saline solution in hospitalized patients with COPD（chronic obstructive pulmonary disease）. Methods In a randomized controlled trial, 71 patients with COPD were divided into two groups. The patients received inhalation of 5 mg salbutamol dissolved in either 4 mL hypertonic （3% ） saline （treatment group,n= 36） or 4 mL normal（0.9 %0） saline （control group, n= 35）. The treatment was repeated twice daily until discharge. Cough, wheezing, pulmonary physical signs,and the length of hospital stay were recorded exactly. Results Wheezing remission time was （2.6 ± 0.7）days in the treatment group and （4.3±1.1）days in the control group （P〈0.01）. Cough remission time was （5.1±1.5）days in the treatment group and （6.9±2.0）days in the control group （P〈0.01）. The moist crackles disappeared at （7.0±0.8）days in the treatment group versus （9.2±0.9）days in the control group （P〈0.01）. Furthermore, the average length of hospital stay de creased from （14.3±2.5）days in the control group to （19.0±3.3）days in the treatment group （P〈0.01）. No obvious adverse effects were observed. Conclusion Inhalation of nebulized 3% hypertonic saline solution and salbutamol is an effective therapy for patients with COPD.
出处
《重庆医学》
CAS
CSCD
北大核心
2011年第24期2427-2428,2437,共3页
Chongqing medicine
关键词
肺疾病
慢性阻塞性
盐水
高渗
沙丁胺醇
pulmonary disease, chronic obstructive
saline solution, hypertonic
albuterol
