摘要
目的探讨葡萄糖-6-磷酸脱氢酶(G6PD)活性对新生儿珠蛋白生成障碍性贫血(THal)的诊断价值。方法将26例新生儿THal患者分为α-THal组和β-THal组,以健康新生儿作为对照组,分别检测红细胞平均体积(MCV)、红细胞分布宽度(RDW)、红细胞脆性(EF)及G6PD活性。结果与对照组比较,α-THal组和β-THal组MCV与EF降低,RDW和G6PD活性增高(P<0.05);α-THal组与β-THal组各指标比较差异无统计学意义(P>0.05)。MCV、EF和G6PD活性诊断THal的准确率分别为92.9%、89.7%和81.7%;G6PD活性诊断THal准确率与MCV比较差异有统计学意义(P<0.05),与EF比较差异无统计学意义(P>0.05)。结论 G6PD活性可作为新生儿THal的辅助诊断指标,检测简单快捷、费用低,易于临床应用。
Objective To explore the clinical value of the activity of glucose-6-phosphate dehydrogenase（G6PD） in the diagnosis of the neonate Thalassemia（THal）.Methods 126 cases of neonates with THal were divided into α-THal and β-THal group,and healthy neonates were enrolled as control group.All enrolled subjects were detected for mean corpuscular volume（MCV）,red blood cell distribution width（RDW）,erythrocyte fragility（EF） and the activity of G6PD.Results Compared with control group,the levels of MCV and EF in α-THal and β-THal groups both decreased obviously,RDW and the activity of G6PD increased observably（P〈0.05）,but no statistical differences of these indexes were found between α-THal and β-THal group（P〉0.05）.The diagnostic accuracy rates of MCV and EF were 92.9% and 89.7% respectively,and that of G6PD was 81.7%,which has statistically difference with that fo MCV（P〈0.05）.Conclusion The activity of G6PD could be used as a subsidiary indicator in the diagnosis of neonate THal.The measurement of G6PD is quick,cheap and easy for clinical utilization
出处
《国际检验医学杂志》
CAS
2011年第12期1285-1286,共2页
International Journal of Laboratory Medicine
关键词
婴儿
新生
地中海贫血
研究
infants,newborn
Thalassemia
research
