摘要
目的采用Meta分析法探讨幽门螺杆菌(Hp)与胃食管反流病(GERD)的关系。方法以GERD组与对照组的HP阳性数的OR值为效应指标,根据一致性检验的结果,选择随机效应模型对OR值进行合并,同时进行偏倚评估。结果纳入总样本量为4 888例,其中GERD组为2 160例,对照组为2 728例;Meta分析合并OR=0.55,95%CI:0.43～0.72。漏斗图形虽不对称,但经敏感性分析结果显示,发表偏倚对研究结果影响较小。结论 HP感染与GERD的发生有关。
[Objective]To study the relationship between helicobacter pylori（Hp） and gastroesophageal reflux disease（GERD） by Meta-analysis.[Methods]OR value of Hp positive number of the GERD group and the control group was regarded as the effect index.According to the results of consistency test,the random effect model was applied to combine the OR value.Meanwhile,the bias estimation was conducted.[Results]A total of 4888 cases were collected,2 160 were in the GERD group and 2 728 were in the control group.After Meta-analysis,OR was 0.55 and 95 % CI was 0.43～0.72.While funnel graphics appeared asymmetrical,the sensitivity analysis showed that results have been affected little by publication bias.[Conclusion]Hp infection may be related to the occurrence of GERD.
出处
《职业与健康》
CAS
2011年第15期1747-1749,共3页
Occupation and Health
关键词
幽门螺杆菌
胃食管反流病
META分析
Helicobacter pylori
Gastroesophageal reflux disease
Meta-analysis
