摘要
目的探讨生长激素对体外受精-胚胎移植(IVF-ET)周期中反复种植失败患者的疗效。方法选择2005年1月至2009年6月在广州医学院第三附属医院生殖中心行IVF-ET反复种植失败患者116例。其中再次行IVF-ET中加用生长激素治疗者为研究组(55例),未使用生长激素治疗者为对照组(61例)。比较两组的妊娠结局。结果研究组受精率、卵裂率、优质胚胎数、胚胎种植率、临床妊娠率[分别为87.9%、82.9%、(4.22±3.13)个、34.5%、25.5%]明显高于对照组[分别为84.0%、75.7%、(2.88±2.73)个、18.0%、9.8%],差异均有统计学意义(P<0.05);研究组HCG日E2水平、子宫内膜厚度[分别为(11.00±4.77)×103nmol/L、(11.29±1.64)mm]较对照组[分别为(9.0±4.8)×103nmol/L、(10.03±1.49)mm]明显改善,差异有统计学意义(P<0.01)。两组用促性腺激素(Gn)天数、Gn用量及获卵数差异无统计学意义(P>0.05)。两组流产率比较,研究组有下降趋势但差异无统计学意义(P>0.05)。结论对IVF-ET反复种植失败的患者再次进行IVF-ET治疗时加用生长激素可提高卵子成熟度,促进子宫内膜发育,改善子宫内膜对胚胎的容受性,从而提高胚胎种植率,增加临床妊娠。
Objective To explore the effect of growth hormone on patients with recurrent implantation failures （RIF）undergoing in vitro fertilization-embryo transfer （IVF-ET）. Methods 116 patients with RIF were divided into two groups. 55 patients in the study group underwent new IVF-ET cycle with adding growth hormone（GH） ,while 61 patients in the control group underwent new IVF-ET cycle without adding GH. Results The fertilization rate, the cleavage rate, the number of good embryos, the implantation rate and pregnant rate in the study group were found to be significantly （ P 〈 0. 05 ） higher than the control group,which were respectively 87.9% vs 84.0% ,82. 9% vs 75.7%, （4. 22 ±3. 13 ）vs （2.88 ± 2. 73） ,34. 5% vs 18. 0% and 25. 5% vs 9. 8%. Meanwhile,there were significantly（P 〈0. 01 ）better in the level of estrogen on HCG clay and thickness of endometfium in the study group, compared with the control group,which were respectively （ 11.0 ± 4. 77 ） ×10^3 nmol/L vs （ 9.0± 4. 8 ） × 10^3 mnol/L and （ 11.29 ± 1.64）mm vs （ 10. 03± 1.49 ）mm. There were no significant difference（P 〉 0.05 ） in Gn days, Gn dose and the number of oocytesin two groups. There was a declining trend of abortion rate in the study group, but no significant difference（ P 〉0. 05 ）. Conclusion Growth hormone is helpful for patients with RIF undergoingthe new IVF-ET cycle. GH can promote oocytes to mature and improve the endometrial receptivity, which are devoted to explain for the better implantation rate and the better pregnant rate.
出处
《中国实用妇科与产科杂志》
CAS
CSCD
北大核心
2011年第8期609-612,共4页
Chinese Journal of Practical Gynecology and Obstetrics
基金
广东省自然基金资助项目(编号205203)
关键词
生长激素
体外受精一胚胎移植
反复种植失败
临床妊娠
growth hormone
in vitro fertilization- embryo transfer
recurrent implantation failure
clinical pregnancy
