摘要
目的：观察硫酸吗啡控释片（美施康定）联合加巴喷丁治疗癌性神经痛的临床疗效。方法：采取随机、对照试验方法，42例中晚期恶性肿瘤合并癌性神经痛的患者，年龄52—76，平均67．2岁，随机分为2组：美施康定单药组（A组）20例，美施康定联合加巴喷丁组（B组）22例，达到疼痛缓解时（VAS≤3分）维持给药直至观察终点，然后比较2组治疗前后美施康定用量、疼痛缓解程度、生活质量、毒副反应。结果：（1）美施康定日均用量B组比A组少（P〈0．05）；（2）疼痛程度改变大小：与治疗前相比2组均有不同程度的缓解，但B组明显大于A组（P〈0．05）；（3）生活质量：在生活质量改善方面，两组均较治疗前有改善，B组生活质量改善较A组明显（P〈0．05）；（4）毒副反应B组较A组轻（P〈0．05）。结论：美施康定联合加巴喷丁能有效控制癌性神经痛，减少美施康定用量及副作用，并能提高患者生活质量。
Objective： To evaluate the analgesic effect of MS-contin combined with gabapentin in the treatment of neuropathic pain in cancer patients. Methods ： 42 patients （ aging from 52 - 76 years old, average 67.2 years old） with advanced malignant tumor and cancerous neuropathic pain were randomly assigned to two groups, the single-agent MS-contin group （group A, 20 cases） and MS-contin combined with gabapentin group （group B, 22 cases）. The dosage and side effects of MS-contin for pain relief （ VAS ≤ 3 points）, and life quality were compared between two groups. Results ： （ 1 ） The average daily dosage of MS-contin in group B was significantly less than that of group A （P 〈 0.05 ） ; （2） Cancerous neuropathic pain was relieved well in both groups and the effect of group B was much better than that of group A ; （3） The life quality of patients in group B were much better than that of group A （ P 〈 0.05 ） ; （4） The side effects observed in group B were much lesser than in group A （P 〈0.05）. Conclusions： MS-contin combined with gabapentin can effectively relieve cancerous neuropathic pain, reduce MS- condin dosage and side effects, and improve the life quality of patients.
出处
《中国疼痛医学杂志》
CAS
CSCD
2011年第8期487-490,共4页
Chinese Journal of Pain Medicine
关键词
美施康定
加巴喷丁
癌性神经痛
MS-contin
Gabapentin
Neuropathic pain in cancer
