摘要
目的：观察艾司洛尔在减轻高血压冠心病患者气管插管反应的作用。方法：选取2008年2月~2010年6月在我院行全麻手术的高血压冠心病患者76例,随机分为对照组和实验组,每组各38例。实验组在插管前5 min给予艾司洛尔（1.5 mg/kg）,对照组常规给药。监测并记录插管后2、5、10 min患者的平均动脉压、心率。结果：插管后2、5、10 min,实验组的平均动脉压分别为（60.80±6.58）mm Hg、（57.62±9.34）mm Hg、（56.73±6.45）mm Hg,对照组的平均动脉压分别为（63.92±6.37）mm Hg、（61.85±8.32）mm Hg、（60.74±7.23）mm Hg;实验组的心率分别为（80.65±4.25）次/min、（80.47±5.47）次/min、（80.54±4.23）次/min,对照组心率分别为（82.64±7.34）次/min、（82.47±6.78）次/min、（82.31±4.66）次/min;实验组平均的脉压和心率较对照组明显降低,差异有统计学意义（P〈0.05）。术中有4例对照组患者出现室性期前收缩等心律失常,实验组患者未发现有心律失常。结论：艾司洛尔能安全有效地抑制高血压冠心病患者由麻醉气管插管引起的心血管反应。
Objective：To investigate the effect of Esmolol on the hemodynamics response to tracheal intubation in patients with hypertension and coronary heart disease.Methods：76 case of patients with hypertension and coronary heart disease underwent anesthesia operation from February 2008 to June 2010 were randomly divided into experiment group and control group,each 38 cases.Esmolol was given to experiment group 5 min before tracheal intubation,conventional treatment was given to control group.Mean arterial pressure（MAP） and heart rate（HR） were monitored 2,5,10 mine after tracheal intu-bation.Results：MAP [（63.92±6.37）mm Hg,（61.85±8.32）mm Hg,（60.74±7.23）mm Hg] and heart rate [（82.64±7.34） times/ min,（82.47±6.78）times/min,（82.31±4.66）times/min] 2,5,10 min after tracheal intubation of control group were significantly higher than experiment group [MAP（60.80±6.58）mm Hg,（57.62±9.34）mm Hg,（56.73±6.45）mm Hg,HR（80.65±4.25）times/ min,（80.47±5.47）time/min,（80.54 ±4.23）times/min]（P0.05）.There were 4 cases of ventricular arrhythmias in control group,but none arrhythmias in experimental group.Conclusion：Esmolol can reduce the hemodynamics response to tracheal intubation effectively and safely in patients with hypertension and coronary heart disease.
出处
《中国医药导报》
CAS
2011年第24期65-66,共2页
China Medical Herald
关键词
艾司洛尔
冠心病
气管插管
Esmolol
Coronary heart disease
Tracheal intubation
