摘要
葛根(Radix Puerariae)为豆科植物野葛Pueraria lobata(Willd.)Ohwi的干燥根。葛根素(Puerarin)是葛根的主要活性成分,现代药理研究表明葛根素具有调节血管张力,抗炎,抗氧化,调节糖脂代谢等药理作用。而葛根素对心血管缺血性损害,糖尿病及其并发症等疾病的治疗作用已经有一定的临床研究基础,本文讨论了葛根素对血管内膜的保护作用,以此提示葛根素干预血管内膜胰岛素抵抗的可能途径及应用前景。
Radix Puerariae is the dried root of Pueraria lobata（Willd.）Ohwi,leguminous vine native.Puerarin,a naturally occurring isoflavonoid,is abundant in the root of the plant Pueraria lobata.Accumulated evidences demonstrate that puerain possesses a variety of biological activities,including regulation of vassle tone,inhibition of inflammatory response,suppression of oxidative stress and amelioration of metabolic disorders etc.Puerarin has been widely applied for the treatment of cardiovascular diseases in the clinic.This paper reviewed the chemiprotection of puerarin agasint endothelial dysfunction and discussed its possible application for the amelioration of insulin resistant endothelial dysfunction.
出处
《海峡药学》
2011年第8期6-9,共4页
Strait Pharmaceutical Journal
