摘要
目的探讨伽玛刀治疗原发性肝癌对患者肝功能的影响。方法研究了67例原发性肝癌患者伽玛刀治疗后6个月内的肝功能生化指标、凝血功能以及肝功能Child-Pugh分级变化,观察出现放射性肝病情况,以及肝功能损伤后的转归等。结果治疗后3个月患者肝功能Child-Pugh分值增高,血清清蛋白下降,凝血功能PT、APTT、TT延长,血清ALT、AST、AKP值升高,且差异均有统计学意义,此外还发生4例放射性肝病,提示肝功能有明显损害。而在治疗后6个月上述各项异常参数显著改善,肝功能明显恢复。结论伽玛刀治疗原发性肝癌可引起肝损伤,肝损伤多以治疗后3个月左右最明显,治疗后6个月左右可以恢复,提示只要掌握好适应证,多数肝癌患者行伽玛刀治疗肝功能可以承受。
Objective To study the effect of gamma knife radiotherapy for primary hepatocellular carcinoma on liver function.Methods To observe the variation of the Child-Pugh grade,blood clotting function and biochemical indexes on 67 patients who are cured by Gamma Knife after six months.Results After 3 months of which cured by gamma knife,the Child-Pugh grade raised,serologic ALB declined,PT,APTT and TT of blood clotting function prolength,and serologic ALT,AST and AKP raised.All of the indexes had statistic difference.Furthermore,4 patiets had radioactive hepatic injury.The indexes of above-mentioned improved prominently after 6 months of cured by gamma knife radiotherapy.Conclution Hepatic injury which was treated by gamma knife radiotherapy was most serious after 3 months,but it recovered after 6 months.This study indicated that most of primary hepatocellular carcinoma patients′ liver fuctions could tolerate by gamma knife radiotherapy so long as we know well of the indication.
出处
《四川医学》
CAS
2011年第8期1214-1216,共3页
Sichuan Medical Journal
关键词
肝肿瘤
放射治疗
肝损伤
伽玛刀
hepatocellular carcinoma
radiational therapy
hepatic injury
gamma knife
