摘要
目的探讨儿童传染性单核细胞增多症(IM)淋巴细胞亚群的变化特点。方法采用流式细胞仪分别检测46例IM急性期患儿、42例恢复期、26例随访期和30例正常对照组的外周血淋巴细胞亚群,并与对照组比较。结果急性期检测CD3+和CD8+细胞明显升高,CD4+细胞明显降低,CD4+/CD8+细胞比值明显降低(P<0.01);恢复期CD4+细胞明显降低,CD4+/CD8+细胞比值明显降低(P<0.01),CD3+变化比较差异无统计学意义。随访期CD3+、CD4+、CD 4+/CD 8+检测结果与对照组比较差异无统计学意义(P>0.05)。结论 EB病毒感染的IM患者淋巴细胞亚群明显发生变化,检测其变化规律对评估IM患儿的细胞免疫功能状况、辅助诊断和指导治疗具有临床意义。
Objective To study the change characteristics of lymphocyte subtypes in children with infections mononucleosis（IM）. Methods Using flow cytometric analysis to detect IM peripheral blood lymphocyte subtype of 46 cases in acute period,42 cases in recovery,26 cases of follow-up and 30 cases in normal control group,and compared with control group.Results CD3＋ and CD8＋ cells increased significantly,CD4＋ cells reduced significantly,and CD4＋/CD8＋ cells ratio decreased obviously in acute period（P0.01）.In recovery period,CD4＋cells reduced significantly,and CD4＋/CD8＋ cells ratio decreased obviously（P0.01）,but CD3＋ results had no obvious differences.The results of follow-up and control group had no obvious differences（P0.05）.Conclusion Paitents with IM who infected EB virus have great changes in peripheral blood lymphocyte subtypes.Its variation can bring obvious clinical significance to IM patients＇ evaluation of cellular immune function condition,auxiliary diagnosis and guide therapy.
出处
《临床医学》
CAS
2011年第8期33-34,共2页
Clinical Medicine
