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无创正压机械通气在治疗急性胰腺炎所致急性呼吸窘迫综合征中的应用 被引量:4

Application of noninvasive positive-pressure ventilation in the treatment of acute respiratory distress syndrome caused by acute pancreatitis
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摘要 目的探讨无创正压机械通气(NPPV)治疗急性胰腺炎并发急性呼吸窘迫综合征(ARDS)的临床价值。方法回顾性分析2007年1月至2010年5月收治的27例急性胰腺炎并发ARDS患者行NPPV治疗的病例资料,对比治疗前后患者心率、呼吸频率、动脉血氧分压(PaO2)、氧合指数(0I)及动脉血二氧化碳分压(PaCO:)的变化情况。结果27例患者中,25例(92.6%)经NPPV治疗后,心率、呼吸频率从上机前的(118.4±13.4)次/min、(32.1±1.7)次/min降低到上机后48h的(81.9±8.5)次/min、(19.9±2.1)次/rain,PaO2、OI及PaC02从上机前的(74.1±5.0)mmHg(1mmHg:0.133kPa)、(148.2±10.0)mmHg、(28.7±1.6)mmHg增加到上机后48h的(110.4±20.8)mmHg、(204.5±71.1)mmHg、(38.4±3.6)mmHg,最终顺利脱机并过渡为文丘里面罩给氧;2例(7.4%)患者呼吸情况恶化,最终改为经口气管插管接有创呼吸机辅助呼吸。结论急性胰腺炎并发ARDS患者使用NPPV治疗的疗效满意。NPPV操作相对简单,容易学习和掌握,并发症少,值得在临床上推广应用。 Objective To evaluate the clinical value of noninvasive positive-pressure ventilation (NPPV) treatment in acute respiratory distress syndrome caused by acute pancreatitis. Methods A retrospective study of 27 cases, with acute respiratory distress syndrome (ARDS) caused by acute panereatitis, who were admitted to our department from Jan 2007 to May 2010 and treated with NPPV, was performed. The changes of heart rate, respiratory rate, Pa02, oxygenation index (0I) and PaCO2 before and after treatment were compared. Results The heart rate, respiratory rate of 25 (92.6%) patients decreased from ( 118.4 ± 13.4)/min, (32.1±l.7)/min to (81.9±8.5)/rain, (19.9 ±2.1)/min; PaOz, OI and PaCO2 increased from (74.1 +5.0)mmHg, (148.2±10.0)mmHg, (28.7 +l.6)mmHg to (110.4 +20.8)mmHg, (204.5 ± 71.1 ) mmHg, (38.4 ± 3.6) nunHg 48 h after NPPV, respectively, and they recovered and were transited to oxygen supply by Venturi mask. 2 (7.4%) patients deteriorated and were transited to invasive positive-pressure ventilation support. Conclusions NPPV could effectively improve oxygenation of patients with ARDS caused by acute pancreatitis. The procedure of NPPV is relatively easy to use and to learn with few complications, and worth of clinical application.
出处 《中华胰腺病杂志》 CAS 2011年第4期237-239,共3页 Chinese Journal of Pancreatology
关键词 胰腺炎 呼吸窘迫综合征 成人 回顾性研究 无创正压机械通气 Pancreatitis Respiratory distress syndrome, adult Retrospective studies Noninvasive positive-pressure ventilation
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参考文献4

  • 1Chan YC, Leung PS. Acute pancreatitis:animal models and recent advances in basic research. Pancreas,2007,34 : 1-14.
  • 2DiMagno MJ, DiMagno EP. New advances in acute pancreatitis. Curr Opin Gastroenterol, 2007,23:494-501.
  • 3Surbatovic M, Jovanovic K, Radakovic S, et al. Pathophysiological aspects of severe acute pancreatitis-associated lung injury. Srp Arh Celok Lek ,2005,133:76-81.
  • 4Bernard GR, Artigas A, Brigham KI ,et al. The American-European consensus on ARDS definition, mechanisms, relevant outcome and clinical trial coordination. Am J Respir Grit Care Med, 1994,149 : 818.

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