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晚期糖基化终产物受体Gly82Ser基因多态性与冠状动脉造影阳性者的相关性研究 被引量：1

The Study of the Relationship between Single-nucleotide Polymorphism of Receptor for Advanced Glycation End Products and Coronary Angiography in a Positive
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摘要 晚期糖基化终产物受体（Receptor for Advanced glycation end products,RAGE）是一种膜蛋白,在单核巨噬细胞、血管内皮细胞、肾系膜细胞、神经细胞及平滑肌细胞等细胞中普遍表达。RAGE作为信号转导受体, Objective To study the role of single-nucleotide polymorphism（SNP） of Receptor for advanced glycation end products（RAGE） in the occurrence and evolution of atherosclerosis.Methods 221 angiographically diagnosed CAD（CAD＋ group） and 208 non-CAD subjects（CAD-group） were enrolled in our study.Subjects with diabetes mellitus were excluded.The genotyping of RAGE SNP was performed by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism.Results the Ser/Ser genotype and the Ser allele in CAD＋group were significantly higher than that in CAD-group（P=0.007 and P0.001 respectively）.The numbers of diseased vessels in Ser/Ser carriers were markedly higher than those in the Gly/Ser and Gly/Gly carriers（both P0.05）.Logistic regression analyses showed the presence of Ser/Ser genotype was a risk factor for CAD（P0.001）.Conclusions The data suggests a positive association between the SNP of RAGE gene and CAD in a non-diabetic Chinese cohort.
作者 侯绪伟 金建芬 韩树利 宋亚微 何秀英
机构地区 杭州市第一人民医院 杭州市西溪街道社区卫生服务中心
出处 《心脑血管病防治》 2011年第4期272-274,I0002,共4页 CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT
关键词 晚期糖基化终产物受体 er基因多态性 冠状动脉造影 相关性 阳性者 单核巨噬细胞 血管内皮细胞 肾系膜细胞 Receptor for Advanced Glycation End Products Single-nucleotide Polymorphism Coronary Angiography
分类号 R541.4 [医药卫生—心血管疾病]
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参考文献13

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二级参考文献25

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共引文献13

同被引文献23

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心脑血管病防治
2011年 第4期

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