摘要
目的:评估了急性脑梗死(ACI)患者治疗前后血浆内皮素-1(ET-1)和血清神经元特异性烯醇化酶(NSE)、神经肽-Y(NPY)水平的变化及临床意义。方法:应用放射免疫分析对32例ACI患者进行了治疗前后血浆ET-1和血清NSE、NPY检测,并与35名正常健康人作比较。结果:在治疗前血浆ET-1和血清NSE、NPY水平均非常显著地高于正常人组(P<0.01),经治疗3个月后与正常人组比较仍有显著性差异(P<0.05)。结论:测定ACI患者治疗前后血浆ET-1和血清NSE、NPY水平对观察病情和预后判定具有重要的临床价值。
Objective To explore the changes of plasma ET-1 and serum NSE,NPY levels both before and after treatment in patients with acute cerebral infarction and their significance.Methods Plasma ET-1 and serum NSE,NPY levels were measured with RIA in 32 patients with acute cerebral infarction both before and after treatment as well as in 35 controls.Results Before treatment plasma ET-1 and serum NSE,NPY levels were significantly higher than those in controls（P0.01）.After for 3 months of treatment,the levels dropped markedly,but still remained significant higher（P0.05）.Conclusion Changes of plasma ET-1 and serum NSE,NPY contents both before and after treatment might be of prognostic importance in patients with acute cerebral infarction.
出处
《放射免疫学杂志》
CAS
2011年第4期381-382,共2页
Journal of Radioimmanology
关键词
急性脑梗死
内皮素-1
神经元特异性烯醇化酶
神经肽-Y
acute cerebral infarction（ACI）
endothelin-1（ET-1）
neuron specific enolase（NSE）
neuropeptide Y（NPY）
