摘要
目的比较不同剂量的瑞芬太尼复合异丙酚用于胃镜检查的麻醉效果。方法选择无痛胃镜检查的患者120例。随机均分为Ⅰ、Ⅱ、Ⅲ、Ⅳ4组,分别缓注（时间〉60秒）瑞芬太尼0.25μg/kg,0.μg/kg,0.5μg/kg和1μg/kg;约1min后静脉给予异丙酚1.0-2.0mg/kg,麻醉起效后开始胃镜检查。按50-100μg/（kg.in）的异丙酚静脉注射维持至术毕。观察患者的各项生命体征和术后恢复情况。结果全部胃镜检查均在麻醉下顺利完成。Ⅲ组和Ⅳ组术中SpO2较麻醉前和Ⅰ、Ⅱ组显著下降（P〈0.05）,各组麻醉恢复时间及离院时间无显著性差异（P〉0.05）。结论 0.25μg/kg、0.5μg/kg瑞芬太尼复合异丙酚用于胃镜检查是安全有效的,而0.75μg/kg和1μg/kg的瑞芬太尼则剂量偏大,可能抑制呼吸。
Objective To compare the anesthetic effect of different doses of remifentanil combined with propofol in painless gastroscopy. Methods 120 patients undergoing painless gastroscopy were randomly and averagely divided into 4 groups：Ⅰ, Ⅱ,Ⅲ,Ⅳ,injected remifentanil slowly（time60s）0.25μg/kg,0.5μg/kg,0.75μg/kg and 1μg/kg respetively. One minute later, injected propofol 1.0～2.0mg/kg to anesthetize patients, then beginning gastroscopy. During gastroscopy, all patients were injected propofol 50-100μg/（kg·min）.To observe vital signs and recovery postoperatively. Results All the gastroscopies were performed successfully under general anesthesia. SpO2 of patients in group Ⅲ and Ⅳ was significantly lower than that in group Ⅰ and Ⅱ（P〈0.05）.Recovery time and discharge time were no significantly difference between groups（P〉0.05）.Conclusion Remifentanil 0.25μg/kg and 0.5μg/kg was effective and safe for gastroscopy, but remifentanil 0.75μg/kg and 1μg/kg was large,because they could depress respiration.
出处
《中国老年保健医学》
2011年第4期38-39,共2页
Chinese Journal of Geriatric Care
关键词
瑞芬太尼
异丙酚
无痛胃镜
remifentanil
propofol
painless gastroscopy
