摘要
目的观察铁屑生品、炮制品和复方制剂七味铁屑丸对环磷酰胺致小鼠贫血模型的治疗作用。方法采用环磷酰胺100 mg/kg的剂量,以0.2 mL/10 g腹腔注射5 d建立贫血小鼠模型,分别以生品、炮制品和七味铁屑丸不同浓度灌胃给药,观察小鼠的恢复情况,并检测各项血液指标。结果与模型组小鼠比较,生品组小鼠体质量持续下降,并有死亡现象;炮制品和七味铁屑丸组,小鼠体重呈上升趋势,血液生化指标有一定恢复趋势,七味铁屑丸组比炮制品组恢复情况好;与模型组比较,炮制品剂量为0.11 g/kg和0.15 g/kg时,血小板的检测结果有显著差异(P<0.05),七味铁屑丸的剂量为0.50 g/kg和0.70 g/kg时,红细胞和血小板有极显著差异(P<0.01)。结论与生铁屑相比,铁屑炮制品能明显增强机体对铁的吸收,从而促进贫血模型的恢复;而七味铁屑丸的作用比铁屑炮制品单独使用时的作用明显。
AIM To observe the treatment for anemic mice with iron powder,product processed with Chebulae Fructus and Qiwei Tiexie Pill.METHODS 0.2 mL/10 g of intraperitoneally injection of cyclophosphamidemice into mice in the dose of 100 mg / kg for five days established model for anemia,then treated respectively with iron powder,product processed with Chebulae Fructus and Qiwei Tiexie Pill of different concentrations.To observe the recovery and test the blood parameters.RESULTS Compared with the control group,mice in iron powder group continued to decline in body weight with a small number of death.Mice in iron powder processed with Chebulae Fructus and Qiwei Tiexie Pill group showed a slight recovery trend in body weight and blood biochemical parameters and the latter group had a more good recovery;The platelet count had significant difference（P 〈0.05） in the processed iron powder in the doses of 0.11 g/kg and 0.15 g/kg,the red blood cells and platelets counts had significant difference（P 〈0.01） in Qiwei Tiexie Pill group in the doses of 0.50 g/kg and 0.70 g/kg.CONCLUSIONThe processed iron powder can significantly enhance the absorption of iron in mice,thereby promote the recovery of anemia.Qiwei Tixie Pill has better curative effects than the processed iron powder does alone.
出处
《中成药》
CAS
CSCD
北大核心
2011年第8期1371-1375,共5页
Chinese Traditional Patent Medicine
基金
"十一五"国家科技支撑计划"藏药诃子制铁屑和制乌头工艺研究"(2007BAI48B02)
关键词
铁屑炮制品
贫血模型
红细胞
白细胞
血红蛋白
血小板
小鼠
processed products of iron
anemia model
RBC
white blood cell
hemoglobin
blood platelet
mouse
