摘要
目的探讨125I放射性粒子近距离照射治疗肝脏恶性肿瘤的近期疗效及副反应。资料与方法按照三维治疗计划系统(TPS)的模拟布源,在螺旋CT导引下局部麻醉进行125I植入,术后1、2、6、12个月随访CT,进行疗效评价。结果17例顺利完成植入手术,无一例发生严重并发症。17例21个病灶中,18个病灶布源满意,满意率85.71%(18/21),5例完全缓解;10例12个病灶部分缓解;稳定2例4个病灶。总有效率80.95%(17/21)。随访2～52个月,5例于半年后失访,2例分别于植入术后7、10个月死亡。另10例中,2例刚植入术后2个月,其他生存1年8例,生存2年3例,生存3年1例,1例已超过52个月。结论CT导引下经皮穿刺植入125I放射性粒子,对肝脏恶性肿瘤有较好局部控制率及较高的安全性。
Objective To study the short-term efficacy and side effects of brachytherapy with radioactive ^125I seeds for the treatment of liver malignant tumor.Materials and Methods Hilar lesions were examined with contrast enhanced CT before implantation,to understand the anatomic relationship between the lesions and main vessels,bile duct.Three-dimensional treatment planning system（TPS） was used to analog the arrangement of the seeds.,^125I seeds were implanted into liver under local anesthesia under spiral CT-guidance.Evaluation of therapeutic effect was conducted by follow-up CT during the 1,2,6th and 12th month after operation.Results 17 cases were implanted successfully,and no severe complications occurred.In 17 cases（21 lesions）,18 lesions were satisfied,the rate of satisfaction was 85.71%（18/21）;5 cases were completely remission;10 cases（12 lesions） were partly remission;2 cases were stable（4 lesions）.The total effective rate was 80.95%（17/21）.During a follow-up period of 2 to 52 months,5 cases lost after 6 months,2 cases were dead after implanting surgery 7 months and 10 months respectively.The other 10 cases,2 cases of just 2 months after seed implantation,the 1-year survival was in 8 cases,2-year survival was in 3 cases,3-year survival was in 1 case,and 1 case had been survived more than 52 months.Conclusion Implantation of radioactive ^125I seeds percutaneous puncture under CT-guidance has a better local control rate and safety to liver malignant tumors.
出处
《临床放射学杂志》
CSCD
北大核心
2010年第1期99-101,共3页
Journal of Clinical Radiology
