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急性冠状动脉综合征患者外周血单个核细胞基质金属蛋白酶-9活性水平的观察

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摘要 目的检测急性冠状动脉综合征（ACS）患者外周血单个核细胞基质金属蛋白酶-9（MMP-9）活性水平并探讨其意义。方法选取35例ACS患者和选10例经冠状动脉造影证实无冠状动脉病变患者（对照组），分离其外周血单个核细胞，酶谱法检测MMP-9活性。结果与对照组比较，ACS患者外周血单个核细胞基质金属蛋白酶-9活性显著增强（P〈0．01）。结论ACS患者循环中单个核细胞MMP-9活性显著增高，可能在不稳定斑块的发生和发展中起着重要作用。
作者 田橙 周志斌 张丽芬
机构地区 中国船舶重工集团公司职工医院内科 武汉科技大学附属天佑医院神经内科
出处 《临床内科杂志》 CAS 2011年第8期565-566,共2页 Journal of Clinical Internal Medicine
关键词 急性冠状动脉综合征 外周血单个核细胞 基质金属蛋白酶-9
分类号 R541 [医药卫生—心血管疾病]
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参考文献9

  • 1Hobeika NJ,Thompson BW,Muhs BE,et al.Matrix metalloproteinases in peripheral vascular disease.J Vesc Surg,2007,45:849-857.
  • 2Konstantino Y,Nguyen TT,Wolk R,et al.Potential implications of matrix metalloproteinase-9 in assessment and treatment of coronary artery disease.Biomarkers,2009,14:118-129.
  • 3Mason DP,Kenagy-RD,Hasenstab D,et al.Matrix metalloproteinase-9 overexpression enhances vascular smooth muscle cell migration and alters remodeling in the injured rat carotid artery.CircRes,1999,85:1179-1185.
  • 4Cho A,Reidy MA.Matrix metalloproteinase-9 is necessary for the regulation of smooth muscle cell replication and migration after arterial injury.Circ Res,2002,91:845-851.
  • 5Aguilem CM,George SJ,Johnson JL,et al.Relationship between type Ⅳ collagen degradation,metalloproteinase activity and smooth muscle cell migration and proliferation in cultured human saphenous vein.Cardiovasc Res,2003,58:679-688.
  • 6Rekhter MD.Collagen synthesis in atherosclerosis:too much and not enough.Cardiovasc Res,1999,41:376-684.
  • 7周志斌,郭毅,王思鸿,李小好,尤玉兰,顾惠娟,丁秋华.基质金属蛋白酶9及转化生长因子β1在人动脉粥样硬化斑块的表达及其与斑块稳定性的关系[J].中国动脉硬化杂志,2006,14(3):217-220. 被引量：23
  • 8Romanic AM,Burns-Kurtis CL,Gout B,et al.Matrix metalloproteinase expression in cardiac myocytes following myocardial infarction in the rabbit.Life Sri,2001,68:799-814.
  • 9Moreno PR,Falk E,Palacios IF.Macrophage infiltration in acute coronary syndromes.Implications for plaque rupture.Circulation,1994,90:775-778.

二级参考文献11

  • 1杨彬,马颖哲,马岩,刘坤.基质金属蛋白酶与动脉粥样硬化[J].吉林大学学报（医学版）,2004,30(5):831-834. 被引量：4
  • 2Bobik A, Agrotis A, Kanellakis P, Dilley R, Krushinsky A, Smimov V, et al. Distioct patterns of transforming growth factor-β isoform and receptor experession in human atherosclerotic lesions: colocalization implicates TGF-β in fibrofatty lesion development [J]. Circulation, 1999, 99 (22): 2 883-891
  • 3Mallat Z, Tedgui A. The role of transfoming growth factor beta in atherosclerosis: novel insights and future perspectives [J]. Curr Opin Lipidol, 2002, 13(50) : 523-529
  • 4Lutgens E, Gijbel M, Smook M, De Muinck ED, Grewal IS, Koteliansky VE,et al. Transforming growth factor-beta mediates balance between inflammation. and fibrosis during plaque progression[ J ]. Arterioscler Thromb Vasc Biol,2002, 22 (6): 975-982
  • 5Reiner Z, Tedeschi-Reiner E. New information on the pathophysiology of atherosclerosis [J]. Lijec Vjesn, 2001, 123 (1-2): 26-31
  • 6Lutgens E, Gorelik L, Daemen MJ. De Muinck ED, Grewal IS. Koteliansky VE,et al. Both early and delayed anti-CD40L antibody treatment induce a stable plaque phenotype [J]. Proc Natl Acad Sci USA, 2000, 13:7464-469
  • 7Steen DK, Ravn HB, Falk E. Insight to the pathophysiology of instable coronary artery disease [J]. Am J Cardiol, 1997, 80(5A): 5E-9E
  • 8Mason DP, Kenagy RD, Hasenstab D, Bowen-Pope DF, Seifert RA, Coats S, et al. Matrix metalloproteinase-9 overexpression enhances vascular smooth muscle cell migration and alters remodeling in the injured rat carotid artery[ J ]. Circ Res, 1999, 85 (12): 1 179-185
  • 9Hong BK, Kwon HM, Lee BK, Kim D, Kim IJ, Kang SM, et al. Coexpression of cyclooxygenase-2 and matrix metalloproteinases in human aortic atherosclerotic lesions [J]. Yonsei Med J, 2000, 41 (1): 82-88
  • 10Delay AM, Brinekerhoff CE. Post-transcriptional regulation of conagenase and stromelysin gene expression by epidermal growth factor and dexamethasone in cultured human fibrobiasis [ J ]. J Cell Biochem, 1992, 50 (4) : 400-410

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临床内科杂志
2011年 第8期

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