摘要
目的:分析大环内酯类药物不良反应(ADR)发生特点与其相关因素,促进临床合理用药。方法:采用回顾性分析方法,对2004年5月—2010年2月间收到的98例大环内酯类药物所致ADR报告表,并分别从药物种类,患者性别、年龄及既往ADR史,给药途径、临床表现、处理方法及结果等数据进行分析。结果:98例大环内酯类引发的ADR中,主要涉及阿奇霉素、罗红霉素与克拉霉素,其中阿奇霉素导致的ADR84例(既往有ADR史16例);通过静脉给药引起ADR72例,除3例严重ADR外,临床表现主要以皮肤及附件、消化系统损害为常见。结论:临床应严格掌握大环内酯类药物的使用适应证,重视对大环内酯类ADR用药监护,以减少或避免ADR发生。
Objective：To analyze the characteristics and factors of adverse drug reaction（ADR） caused by macrolides for their rational use in clinic. Methods：98 ADR cases collected from May 2004 to February 2010 in our hospital were analyzed retrospectively in respect of drug species, patients＇gender, age, ADR history, route of medication, clinic manifestations, processing methods and results. Results： Altogether 3 kinds of drugs were involved ADR, and there were 84 cases caused by azithromycin. 16 patients had the record of ADR history and 72 ADR cases were induced by IV drop drugs. There were 3 serious ADR cases. The main clinic manifestations of ADR were skin and local lesion,then digestive system damage, etc. Conclusion：The indications of macrolides should be controlled strictly, and monitoring of its administration should be emphasized in clinic to decrease and avoid the occurrence of ADR.
出处
《抗感染药学》
2011年第3期214-216,共3页
Anti-infection Pharmacy
