摘要
目的:比较单用更昔洛韦与联合阿昔洛韦治疗小儿巨细胞病毒肺炎的效果。方法:将确诊为巨细胞病毒肺炎的158例患儿随机分成A、B两组:A组(78例)更昔洛韦5 mg/(kg.次),每12小时静脉滴注1次,治疗14 d后改为1次/d,维持7 d;B组80例,在A组基础上加用阿昔洛韦10 mg/(kg.次),每8小时静脉滴注1次,持续14 d。结果:A组有效率为83.3%,不良反应率为16.7%;B组有效率为93.8%、不良反应率为20.0%,两组之间有效率比较,差异有统计学意义(P<0.05),不良反应率比较,差异无统计学意义(P>0.05)。结论:更昔洛韦联合阿昔洛韦治疗小儿巨细胞病毒肺炎的效果更好,且不良反应无比较差异无统计学意义(P>0.05)。
Objective To compare the efficacy of ganciclovir alone and combined with acyclovir against children with cytomegalovirus pneumonia.Method Total 158 children with cytomegalovirus pneumonia were randomly divided into group A and B.Patients in group A（n=78） were treated with ganciclovir 5 mg/kg at a time,intravenous drip every 12 hours,continuously using for 14 days,then maintenance treatment with 5 mg/kg intravenous drip every day for 7 days.Patients in group B（n=80） were treated with the same as those in group A and acyclovir 10 mg/kg at a time,intravenous drip every 8 hours,continuously using for 14 days.Results The total effective rate in group A was 83.3% and that in group B was 93.8%,there were obvious difference between group A and group B（P0.05）;the total adverse effect incidence in group A was 16.7% and in group B was 20.0%,with no significant differences（P0.05）.Conclusion Ganciclovir and acyclovir have better effect against children with cytomegalovirus pneumonia,and there are no significant differences between the two groups in the rates of adverse reaction.
出处
《吉林医学》
CAS
2011年第25期5237-5238,共2页
Jilin Medical Journal
