摘要
目的观察在常规药物治疗基础上采用心理康复治疗方法治疗乙型病毒性肝炎肝硬化失代偿期的临床疗效及对相关指标的影响。方法将84例乙型病毒性肝炎肝硬化失代偿期患者随机分为2组。对照组42例予注射用还原型谷胱甘肽1.2 g,每日1次静脉滴注,恩替卡韦片1 mg,每日1次口服。治疗组42例在对照组治疗基础上予心理康复治疗。2组均以6个月为1个疗程。观察2组症状、体征变化,观察并统计治疗前后Ch ild-Pugh积分,检测治疗前后血清丙氨酸氨基转移酶(ALT)、总胆红素(TB iL)、乙肝病毒脱氧核糖核酸(HBV-DNA)、肝纤维化4项指标血清透明质酸(HA)、尿粘连蛋白(LN)、Ⅲ型前胶原(PC-Ⅲ)、Ⅳ型胶原(Ⅳ-C)。结果治疗组好转率66.67%,对照组好转率40.48%,治疗组好转率高于对照组(P<0.05);治疗组治疗后Ch ild-Pugh积分、HA、PC-Ⅲ、LN、ALT、TB iL、HBV-DNA与本组治疗前比较差异均有统计学意义(P<0.05),对照组治疗后Ch ild-Pugh积分、HA、LN、ALT、TB iL、HBV-DNA与本组治疗前比较差异均有统计学意义(P<0.05),2组治疗后Ch ild-Pugh积分、HA、PC-Ⅲ、ALT组间比较差异均有统计学意义(P<0.05),治疗组改善优于对照组;治疗12个月后随访,治疗组死亡率7.1%,对照组死亡率11.9%,治疗组死亡率低于对照组(P<0.05)。结论在常规药物治疗基础上采用心理康复治疗方法治疗乙型病毒性肝炎肝硬化失代偿期能有效改善肝功能及预后。
Objective To observe the effect of psychological rehabilitation treatment on the virus hepatitis B cirrhosis related indicators in decompensation period on the basis of routine therapy.Methods 84 patients with hepatitis B cirrhosis were randomly divided into 2 groups.42 cases in control group received Glutathione injection 1.2 g,infusion of once a day,Entecavir tablets 1 mg,oral a pills a day.42 patients in treatment group received psychological rehabilitation treatment on the basis of therapy of control group.The course was six months in two groups.The changes of symptoms,signs and Child-Pugh score were observed in two groups.ALT,TBiL,HBV-DNA,HA,LN,PCⅢ and IVC in serum were detected before and after treatment.Results The improvement rate in treatment group（66.67%） was higher than that in control group（40.48%,P0.05）.There were significant differences between before and after treatment on Child-Pugh score,HA,PCⅢ,LN,ALT,TBiL and HBV-DNA in treatment group（P0.05）.There were significant differences between before and after treatment on Child-Pugh score,HA,LN,ALT,TBiL and HBV-DNA in treatment group（P0.05）.There were significant differences between two groups on Child-Pugh score,HA,PCⅢ and ALT after treatment（P0.05）.The death rate in treatment group（7.1%） was lower than that in control group follow-up after 12 months of treatment（11.9%,P0.05）.Conclusion Psychological rehabilitation treatment on the basis of routine therapy can effectively improve liver function and prognosis on the treatment of virus hepatitis B cirrhosis in decompensation period.
出处
《河北中医》
2011年第8期1136-1138,共3页
Hebei Journal of Traditional Chinese Medicine
