Megsin与肾脏疾病
摘要
肾小球系膜细胞(glomerular mesangial cell,GMC)是肾脏重要的固有细胞之一,维持着肾脏的组织结构和生理功能,具有产生细胞外基质(extracellular matrix,ECM)、分泌细胞因子(cytokine,CK)、吞噬和清除异物等多种功能,同时也参与了肾小球疾病尤其是系膜增生性疾病的发生、发展。Megsin是近10年来被新认识的GMC优势表达基因,本文就megsin与肾脏疾病的关系做一综述。
出处
《临床肾脏病杂志》
2011年第8期377-379,共3页
Journal Of Clinical Nephrology
基金
河北省自然科学基金项目(C2010000583)
河北省卫生厅重大项目(20090008)
参考文献19
-
1Cove-Smith A, Hendry BM. The regulation of mesangial cell proliferation. Nephron Exp Nephrol, 2008, I08 : e74-79.
-
2Miyata T, Li M, Yu X, et al. Megsin gene: Its genomic analysis, pathobiological functions, and therapeutic perspectives. Current Genomics, 2007,8 : 203-208.
-
3Lomas DA, Carrell RW. Serpinopathies and the conforrnational dementias. Nat Genet Rev, 2002,3:759-767.
-
4Inagi R, Miyata T, Nangaku M, et al. Transcriptional regulation of a mesangium-predominant gene, megsiru J Am Soc Nephrol, 2002,13 : 2715-2722.
-
5Evdokimova V, Ovehinnikov LP, Sorensen PH. Y-box binding protein 1 : Providing a new angle on translational regulation. Cell Cycle, 2006,5 : 1143-1147.
-
6Ohtomo S, Nangaku M, Izuhara Y, et al. The role of megsin, a serine protease inhibitor, in diabetic mesangial matrix aceumulation. Kidney Int, 2008,74 : 768-774.
-
7Inagi R,Miyata T, Imasawa T, et al. Mesangial cell-predominant gene, megsirL Nephrol Dial Transplant, 2002, 17(Suppl 9):32- 33.
-
8Nangaku M, Miyata T, Suzuki D, et al. Cloning of rodent megsin revealed its up-regulation in mesangioproliferative nephritis. Kidney International, 2001,60: 641-652.
-
9Miyata T, Inagi R, Nangaku M, et al. Overexpression of the serpin megsin induces progressive mesangial cell proliferation and expansion. J Clin Invest, 2002,109: 585-593.
-
10Inagi R, Yarnamoto Y, Nangaku M, et al. A severe diabetic nephropathy model with early development of nodule-like lesions induced by megsin overexpression in RAGE/iN(kS transgenic mice. Diabetes, 2006,55 : 356-365.
-
1刘建平,扈昕虹,曲宏,曲娴.激光治疗腺性膀胱炎(附16例报告)[J].吉林医学院学报,1996,16(3):49-49.
-
2乳腺增生会癌变吗?[J].医药保健杂志,2009(2):62-62.
-
3陈国生.火针为主治疗弥漫性色素绒毛结节性滑膜炎1例临床报告[J].黑龙江中医药,2008,37(3):33-33.
-
4张红梅,刘肖峰.中西医结合治疗乳腺增生病120例疗效观察[J].新疆中医药,2007,25(4):67-68. 被引量:1
-
5范浩,邢新.瘢痕疙瘩内药物注射治疗的研究进展[J].中国美容整形外科杂志,2015,26(11):653-655. 被引量:3
-
6李登,马若凡.色素沉着绒毛结节性滑膜炎的研究进展[J].中华关节外科杂志(电子版),2012,6(5):71-73. 被引量:10
-
7刘传政.左尺骨纹状增生症[J].医学影像学杂志,1994,4(4):228-245.
-
8施君瑶.1376例乳腺疾病患病情况分析[J].中国乡村医药,2002,9(9):55-56.
-
9陈军,董宏然,王全美.关节镜下全滑膜切除术治疗膝关节弥漫色素沉着绒毛结节性滑膜炎的疗效分析[J].颈腰痛杂志,2010,31(4):310-311.
-
10刘政江,黄明亮,苟举民.腺性膀胱炎97例诊断与治疗体会[J].实用医药杂志,2016,33(10):886-887. 被引量:6