摘要
川崎病发病率逐年上升。此病多见于婴幼儿,常累及冠状动脉,20%～30%可发生冠状动脉瘤或冠状动脉扩张,心血管系统的并发症是导致患儿死亡的主要原因。近年来,很多研究发现,患儿在川崎病病程的各期均可能存在不同程度的冠状动脉损伤和心肌缺血,同时也出现了很多检验项目和检查手段用于评价冠状动脉损伤和心肌缺血的程度,如放射性核素心肌扫描、平板运动试验、药物负荷超声心动图、血浆同型半胱氨酸、血清缺血修饰清蛋白、基质金属蛋白酶9等。若能早期发现患儿的冠状动脉、心肌的损害,并进行干预,将会极大提高患儿的生存率和生活质量。本文对川崎病患儿冠状动脉损伤及心肌缺血研究进展进行综述。
The incidence of Kawasaki Disease（KD） is increasing.This disease is common in young children,often with the coronary arteries involved.Coronary artery aneurysms and ectasia are seen in 20%~30% cases.Cardiovascular complications are the main causes of death.Recently,more and more studies have found that various degrees of coronary damage and myocardial ischemia existed in all phases of KD.Meanwhile,a number of testing methods have been employed to estimate the degrees of coronary damage and myocardial ischemia,including radionuclide techniques for evaluating cardiomyopathy,exercise treadmill test,echocardiography under drug stress,plasma homocysteine detection,ischemia modified albumin detection,matrix metalloproteinase-9 detection,and so on.Early detection and intervention of coronary damage and myocardial ischemia might result in higher survival rate and better quality of life.This paper reviews recent research on status of coronary damage and myocardial ischemia in KD patients.
出处
《中国全科医学》
CAS
CSCD
北大核心
2011年第27期3079-3082,共4页
Chinese General Practice
关键词
黏膜皮肤淋巴结综合征
冠状血管
心肌缺血
Mucocutaneous lymph node syndrome
Coronary vessels
Myocardial ischemia
