摘要
维库溴铵与苯磺阿曲库铵应用于肝肾功能正常者33例、末期肾衰病人26例、阻塞性黄疸病人20例。静注维库溴铵与苯磺阿曲库铵初剂量分别为0.1mg/kg和0.5mg/kg,每次追加剂量分别为0.05mg/kg和0.25mg/kg,术中用4个成串刺激(TOF)监测肌松程度。应用2药于肾衰组,除起效时间较其他2组明显缩短外,其他参数无差异,前者用于阻黄病人时,TOF在恢复过程中第4(T_4)与第1(T_1)个刺激反应强度之比(RTOF)0.25和恢复指数均有明显延长,提示有积蓄作用,使用时应慎重。
Efficacies of muscular relaxation, with atracurium besilate 0.5 mg/kg or vecuronium 0.1 mg/kg given iv as an initial dose, and 0.25 mg/kg or 0.05 mg/kg respectively as maintenance doses were compared clinically, Duration of action, RTOF (recovery ,of train of four)0.25 and recovery indices were measured.Following the injection of either vecuronium or atracurium besilate in 33 patients with normal liver an,d kidney functions, the parameters showed anon-significant difference. In 26 patients at the terminal stage of aqute renal failure, both atracurium besilate and vecuronium displayed a quicker .onset time. In 20 patients with chqlestasis, atracurium besilate was well tolerated without any change in parameters, but vecuronium showed the RTOF 0.25 and recovery indices prolonged. Evtdences are apperent that vecuronium presents some drug retention under this circumstance
出处
《新药与临床》
CSCD
北大核心
1990年第5期282-284,共3页
关键词
维库溴铵
苯磺阿曲库铵
肌松驰
vecuroniura
Atrapurium besilate
cholestasis
acute kidney failure
muscle relaxation
