摘要
非甾体类解热镇痛药大多为口服制剂,在口服困难的患者中存在很大的缺陷,2009年美国FDA首次批准上市了首个治疗疼痛和发热的布洛芬静脉注射制剂。本文介绍了布洛芬注射液的制剂开发、药理学、药动学、临床应用、不良反应以及与其他药物的相互作用等,供临床参考,以促进临床安全合理用药。
Most of non-steroidal anti-inflammatory drugs （NSAIDs） are oral dosage forms which can＇t be administered when patients fail to take the drug orally. A formulation of ibuprofen for intravenous was approved by the US FDA for moderate to severe pain and for the reduction of fever. In this paper, the development of preparation, pharmacology, pharmacokinetics, clinical applications, adverse reactions, drug interactions, et al. of ibuprofen injection are reviewed in order to provide a reference for clinical applications and promote rational drug use.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2011年第8期584-587,共4页
Chinese Journal of New Drugs and Clinical Remedies
关键词
布洛芬
制剂开发
药理学
药动学
临床试验
ibuprofen
preparation development
pharmacology
pharmacokinetics
clinical trials
