摘要
目的通过对病毒感染急性期患者外周血淋巴细胞亚群的检测,比较其与正常对照组的差异,初步探讨病毒感染急性期宿主细胞免疫功能的变化并分析其意义。方法收集2010～2011年感染科住院收治的病毒感染急性期患者24例,使用流式细胞仪检测其外周血T细胞亚群,与正常对照组比较,分析其差异及临床意义。结果与正常对照相比,病毒感染患者外周血B细胞减少,T细胞及CD8+T细胞比率及计数升高;CD8+CD38+T细胞比率及计数明显升高。结论病毒感染急性期患者体内存在T淋巴细胞亚群失衡和细胞免疫功能紊乱,这可能与病毒的清除及病毒感染后宿主的免疫损伤相关。
Objective To investigate The change and significance of host＇s cellular immunity in patients with acute virus infection throuth comparing peripheral blood lymphocyte subsets between viral infected patients and normal controls. Methods Flow cytometry was used to detect the peripheral blood lymphocyte subsets in 24 patients with acute virus infection and 20 health blood donors. Results Compared with normal controls, the count and the proportion of lymphocytes, T - lymphocytes, CD8＋ T cells and CD8＋ CD38＋ T ceils increased in patients with acute virus infection. Conclusion There was imbalance in peripheral blood lymphocyte subsets and turbulence in cellular immunity in patients with acute virus infection, which might be associated with clearance of virus and immune injury after virus infection.
出处
《临床和实验医学杂志》
2011年第17期1391-1393,共3页
Journal of Clinical and Experimental Medicine
基金
北京市中医青年科学研究资助项目(2009)
关键词
病毒感染
T淋巴细胞亚群
免疫损伤
Virus infection
T - lymphocyte subsets ： Immune injury
