3Hanna N,Frances A.Shepherd,Frank V.Randomized phaseⅢtrial of pemetrexed versus docetaxel in patients with nonnons-mall cell lung cancer previously treated with chemotherapy[J].J Clin Oncol,2004,22:1589-1597.
4Yang CH,Simms L,Park K.Efficacy and safety of cisplatin/pemetrexed versus cisplatin/gemcitabine as first-line treatment in east asian patients with advanced non-small cell lung cancer:results of an exploratory subgroup analysis of a phaseⅢtrial[J].J Thorac Oncol,2010,5:688-695.
5Scagliotti GV,Parikh P,von Pawel J,et al.PhaseⅢstudy com-paring cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer[J].J Clin Oncol,2008,26:3543-3551.
6Giovannetti E,Mey V,Nannizzi S,et al.Cellular and pharma-cogenetics foundation of synergistic interaction of pemetrexed and gemcitabine in human non-small cell lung cancer cells[J].Mol Pharmacol,2005,68:110-118.
7Pirker R,MinarW.Chemotherapy of advanced non-small cellLung cancer[J].Front Radiat TherOncol,2010,42:157-163.
9CALVERT H.An overview of folate metabolism:Features rel-evant to the action and toicities of antifolate anticancer agents[J].Sem in Oncok,1999,26(2suppl 6):3.
10Hanna N,Shepherd FA,Fossella FV,et al.Randomized phaseIII trial of pemetrexed versus docetaxel in patients with nonsmall-cell lung cancer p reviously treated with chemotherapy[J].J Clin Oncol,2004,22(9):1589-1597.