摘要
目的探讨新生儿呼吸合胞病毒下呼吸道感染的临床特点。方法选取2008年5月-2011年4月,在医院进行治疗的呼吸合胞病毒下呼吸道感染260例新生儿为研究对象,对其采用氧疗、雾化吸入及抗病毒、抗菌药物治疗,后将其治疗有效率、住院时间及治疗前后的血清IL-4、IL-6、IL-12、CRP、IgE及外周血T淋巴细胞亚群水平进行统计比较。结果 260例患儿痊愈239例,好转20例,无效1例,总有效率为99.62%,住院时间为(12.8±2.8)d,治疗后IL-4、IL-6、IL-12分别为(7.55±2.69)、(16.69±7.14)、(56.48±13.39)ng/L,CRP为(6.88±2.39)mg/L,CD8+为(26.52±5.69)%均高于治疗前;治疗后IgE为(808.34±205.30)μg/L,CD3+、CD4+分别为(63.12±5.20)%、(45.58±5.20)%,CD4+/CD8+为(1.68±0.43)%,均高于治疗前,治疗前后差异有统计学意义(P<0.05)。结论经合理治疗,新生儿呼吸合胞病毒下呼吸道感染治疗效果较佳,可显著改善炎性因子及免疫状态。
OBJECTIVE To study the clinical characteristics of newborns with respiratory syncytial virus and lower respiratory tract infection.METHODS A total of 260 newborns with respiratory syncytial virus and lower respiratory tract infection in our hospital from May 2008 to Apr 2011 were selected as research object.The treatment effect of oxygen therapy,atomization,antiviral drugs and antibiotics,and the hospitalization time and serum IL-4,IL-6,IL-12,CRP,IgE and peripheral blood T lymphocyte subsets of patients before and after the treatment were analyzed and compared.RESULTS Totally 239 cases of 260 patients were cured,20 cases were improvements,1case was ineffective,hospitalization time were（12.8±2.8）d,levels of serum IL-4,IL-6,IL-12,CRP and CD8＋ after the treatment were（7.55±2.69）ng/L,（16.69±7.14）ng/L,（56.48±13.39）ng/L,6.88±2.39）mg/L and（26.52±5.69）%,they were higher than（41.58±8.42）ng/L,（90.25±12.42）ng/L,（20.57±5.41）ng/L,（15.96±6.82）mg/L,（36.59±5.33）% before the treatment,IgE,CD3＋,CD4＋,CD4＋/CD8＋ after the treatment were（808.34±205.30）μg/L,（63.12±5.20）%,（45.58±5.20）%,（1.68±0.43）%,they were lower than that before the treatment,there were significant or very significant differences.CONCLUSION The effects of the treatment for newborns with respiratory syncytial virus and lower respiratory tract infection are better,and it can significantly improve the inflammatory factors and immune state.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2011年第18期3823-3825,共3页
Chinese Journal of Nosocomiology
关键词
新生儿
呼吸合胞病毒
下呼吸道感染
疗效
Newborns
Respiratory syncytial virus
Lower respiratory tract infection
Curative effect
