摘要
目的观察浙江省象山县红十字台胞医院和象山县第一人民医院恶性肿瘤患者嗜麦芽寡养单胞菌(SMA)感染的分离及其耐药性分析。方法对2007年1月-2011年1月临床送检的各种标本中分离出的65株SMA进行培养鉴定和耐药性分析。结果象山地区2所医院分离的65株SMA标本来源以呼吸道为主,占52.3%,其他依次为尿液占26.2%,血液占12.3%,胸水占4.6%,腹水占1.5%;65株SMA对氨苄西林、头孢唑林、头孢呋辛和亚胺培南表现出100.0%的耐药;对头孢菌素类抗菌药物,如头孢曲松、头孢噻肟、头孢吡肟和头孢他啶的耐药率较高,分别为95.4%、92.3%、83.1%和75.4%;对氨基糖苷类抗菌药物:庆大霉素和阿米卡星的耐药率为81.5%和83.1%;对喹诺酮类较为敏感,对环丙沙星、加替沙星和左氧氟沙星的敏感率分别为81.5%、90.8%和83.1%;对米诺环素最为敏感,敏感率达95.4%。结论象山地区2所医院,恶性肿瘤患者感染的SMA耐药较为严重,临床在抗感染治疗中,应根据药敏试验结果合理应用抗菌药物,避免滥用抗菌药物。
OBJECTIVE To observe the distribution and drug resistance of Stenotrophomonas maltophilia in malignant tumor patients.METHODS From Jan 2007 to Jan 2011,a total of 65 strains of S.maltophilia were cultured and tested drug resistance.RESULTS Of 65 strains of S.maltophilia,respiratory tract was the main fungal infection site,52.3%,and then the next was urine,accounting for 26.2%,blood,accounting for 12.3%,pleural effusion,accounting for 4.6%,ascites,accounting for 1.5%.65 S.maltophilia to ampicillin,cefazolin,cefuroxime and imipenem demonstrated 100.0% of drug resistance rate;to cephalosporin antibiotics such as ceftriaxone,cefotaxime,cefepime and ceftazidime,showed high resistance,were 95.4%,92.3%,83.1% and 75.4%;to aminoglycoside antibiotics such as gentamicin and amikacin were 81.5% and 83.1%.More sensitive to quinolones,ciprofloxacin,gatifloxacin and levofloxacin,sensitivity rates were 81.5%,90.8% and 83.1%;the most sensitive to minocycline,sensitive rate of 95.4%.CONCLUSION The drug resistance of S.maltophilia in cancer patients in hospital is serious,and clinical treatment with antimicrobial should be rational based on the susceptibility test results.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2011年第18期3947-3949,共3页
Chinese Journal of Nosocomiology
关键词
恶性肿瘤
嗜麦芽寡养单胞菌
耐药性
Malignant tumor
Stenotrophomonas maltophilia
Drug resistance
