摘要
目的:观察双醋瑞因治疗骨关节炎的临床疗效。方法:双醋瑞因组50mg/d,美洛昔康组15mg/d,1个月为1疗程,持续1～3个疗程,随访1～3月。结果:经1疗程治疗,有效率分别是62.22%和68.33%,3疗程后,有效率分别是84.44%和71.67%。双醋瑞因组和对照组在主要疗效指标(步行痛、上下楼梯痛)和次要疗效指标(关节压痛)均较治疗前明显改善,随访期(停药1个月后),双醋瑞因能持续发挥药效,以上各项疗效参数较治疗结束时变化不大。但在对照组.随访期与治疗结束时相比,步行痛、上下楼梯痛和关节压痛程度有所加重。在观察期间,双醋瑞因出现不良反应约为5%,主要为轻度腹泻及腹部轻微疼痛,持续治疗后绝大多数可自行消失,美洛昔康组出现不良反应约为6%,主要为胃肠道反应,如恶心、呕吐等,停用后可消失。结论:应用双醋瑞因治疗膝骨关节炎疗效肯定,而且双醋瑞因的作用持久,无严重不良反应发生,安全性好。
Objective：To observe the clinical efficacy of diacerein treatment of osteoarthritis.Methods：Diacerein group of 50mg/d,meloxicam group of 15mg/d,1 month for 1 course of treatment,for 1 to 3 courses,followed up by 1 to 3 months.Results：After 1 course of treatment,rates were 62.22% and 68.33%,3 courses,the rates were 84.44% and 71.67%.Primary efficacy indicators （walking pain,stair activity pain） and secondary efficacy indicators （joint tenderness）,in diacerein group and control group,were significantly improved compared with before treatment.During the follow-up period （1 month after drug withdrawal）,diacerein can continue to work and efficacy of the above parameters changed little over the end of treatment.However,in the control group,follow-up period compared with the end of treatment,the efficacy in walking pain,stair activity pain and joint tenderness,has increased.During the observation period,diacerein was about 5% of adverse reactions,involving mild diarrhea and mild abdominal pain,which may disappear after treatment.Meloxicam is about 6% of adverse reactions,involving gastrointestinal reactions,such as nausea,vomiting,etc.,which may disappear after the drug withdrawal.Conclusion：Diacerein is effective in treatment of knee osteoarthritis and works much longer,with good safety but no serious adverse events.
出处
《医学信息（中旬刊）》
2011年第9期4384-4384,共1页
Medical Information Operations Sciences Fascicule
