摘要
三唑类化合物作为药物广泛应用于临床,是目前药物研究开发的重点领域之一.越来越多的高活性、低毒性、不良反应少、多药耐药性小、生物利用率高、药代动力学性质好、药物靶向性强、给药方式多样化、广谱、高疗效的三唑类化合物作为候选药物或药物用于临床医治多种疾病,显示出了三唑类化合物在医药领域的巨大开发价值和潜在的宽广应用.本文结合自己的工作,参考国内外近五年文献系统地综述了三唑类化合物作为药物在整个医药领域的研究与开发近况,包括抗真菌、抗细菌、抗结核、抗癌、抗病毒、抗炎镇痛、抗惊厥等,并展望其发展趋势与前景.希望该评论有助于为高活性低毒性三唑类医药合理设计提供新思路.
Triazole compounds as medicinal drugs are extensively used in clinic, and are currently one of the most important fields in the researches and developments of drugs. More and more triazole compounds, with strong pharmacological activity, low toxicity, less adverse effects, fewer multi-drug resistances, high bioavailability, good pharmacokinetics property and drug-targeting, diversity of drug administration, broad spectrum, better curative effect etc. are frequently employed as candidates or clinical drugs for the therapy of various types of diseases, which have showed their large development value and wide potential as medicinal agents. Combining with authors＇ researches and referring other works from literatures in recent 5 years, this work systematically reviewed the new researches and developments of the whole range of triazole compounds as medicinal drugs for the first time, including antifungal, antibacterial, anti-tuberculosis, anticancer, antivirus, anti-inflammatory, anti-convulsion and so on. The perspectives of the foreseeable future in the research and development oftriazole compounds as medicinal drugs are also presented.
出处
《中国科学：化学》
CAS
CSCD
北大核心
2011年第9期1429-1456,共28页
SCIENTIA SINICA Chimica
基金
西南大学人才引进基金(SWUB2006018)
西南大学高新技术培育基金(XSGX0602)
重庆市自然科学基金(CSTC2007BB5369 & CSCT2009BB5296)
国家人事部回国人员重点项目(2002-99)资助
关键词
三唑
抗真菌
抗细菌
抗结核
抗癌
抗病毒
抗炎镇痛
抗惊厥
triazole, antifungal, antibacterial, anti-tuberculosis, anticancer, antivirus, anti-inflammatory, anti-convulsion
