摘要
目的探讨血管内皮生长因子（VEGF）和肿瘤坏死因子（TNF—α）在子宫内膜异位症（EMS）患者血清和腹腔液中的表达及其对临床的指导意义。方法采用双抗体夹心ELISA法检测子宫内膜异位症患者血清中VEGF和TNF—α水平，并进行相关性分析。结果EMS组患者血清和腹腔液中TNF—α和VEGF水平较对照组高，差异有显著性（P〈0．05）。两组患者血清和腹腔液中TNF—α水平和VEGF水平在Ⅲ。Ⅳ期均明显高于I～Ⅱ期，差异有显著性（P〈0．05）。结论EMS患者血清和腹腔液中TNF—α和VEGF水平明显升高，且随疾病的发展而逐步升高，说明VEGF和TNF—α在EMS的发生发展中起重要作用，并有望成为EMS的辅助性诊断指标。
Objective To investigate the expression of vascular endothelial growth factor （VEGF） and tumor necrosis factor （TNF -α） in the endometriosis （EMS） in serum and peritoneal fluid and its effect on clinical significance. Methods The double - antibody sandwich ELISA endometriosis was detected in serum levels of VEGF and TNF - α, and do a correlation analysis. Results EMS patients in peritoneal fluid and serum levels of TNF - α and VEGF was higher than those of the control group, there is statistically significant difference （ P 〈 0. 05）. Two groups of patients in the peritoneal fluid and serum TNF - α levels and VEGF levels in stage Ⅲ - Ⅳwere significantly higher than those the I - Ⅱ period, the difference was statistically significant （ P 〈 0.05 ）. Conclusions EMS in perho- Meal fluid and serum TNF - α and VEGF levels were significantly increased, and with the development of the disease increased gradually, indicating that VEGF and TNF - α in the development of EMS, play an important role, and is expected to be EMS, auxiliary diagnostic index.
出处
《医药论坛杂志》
2011年第15期27-28,31,共3页
Journal of Medical Forum
