摘要
十溴联苯醚(BDE209)是一种具有持久性有机污染物特征的溴系阻燃剂,可在生物体代谢生成更高毒性的化合物.本文利用从人体粪便中提取的微生物以及通过人体肠道微生态系统模拟装置培养的人体肠道微生物,在体外条件下研究BDE209在人体肠道微生物作用下的代谢.结果表明在为期10d的反应时间里,BDE209含量保持稳定,在气相色谱-质谱联用仪(GC-NCI-MS)的色谱图中也没有检测到可能的脱溴代谢产物,说明BDE209没有发生显著的脱溴代谢作用.
Decabromodiphenyl ether （BDE209） is a persistent organic pollutant that is used as brominated flame retardant. In organisms, it could be metabolized into compounds that have higher toxicity than BDE209 itself. In the present study, the metabolism of BDE209 was investigated by human gut microbes obtained from feces and gut microbes incubated using the Simulator of the Human Intestinal Microbial Ecosystem. The results showed that the concentrations of BDE209 in the incubation solution did not decease during incubation （10 d）. Debrominated metabolites were not found in chromatograms from gas chromatography-negative chemical ionization-mass spectrometry. There was no evidence that the human gut microbes could metabolize BDE209 through debromination.
出处
《科学通报》
EI
CAS
CSCD
北大核心
2011年第25期2139-2145,共7页
Chinese Science Bulletin
基金
国家自然科学青年基金(20807026)
上海市重点学科(S30109)资助项目
关键词
肠道微生物
体外实验
代谢
十溴联苯醚
gut microbes
in vitro test
metabolism
decabromodiphenyl ether （BDE209）
