摘要
目的探讨ICE方案（异环磷酰胺、卡铂、依托泊苷）治疗复发和难治性非霍奇金淋巴瘤（NHL）的近期疗效和不良反应。方法25例复发和难治性NHL采用ICE方案治疗，21d为1个周期。观察疗效和不良反应。结果25例均能评价疗效，总有效率76．0％（19／25），总缓解率（RR）为60．0％（15／25），毒副反应主要为白细胞和血小板减少，但均为可逆，未出现因化疗毒性而死亡患者。结论ICE方案是治疗复发和难治性NHL安全有效的解救方案，缓解率高，化疗耐受性好。
Objective To evaluate the short-term effect and side effects of ICE regimen treating the patients with relapsed and refractory non-Hodgkin＇s lymphoma（NHL）. Methods Twenty-five patients with relapsed and refractory NHL were treated with ICE regimen. Treatment was repeated every 3 weeks. Results The total effective rate was 76.0% for 25 patients,The response rate（RR） was 60.0%. The main side effects were marrow suppression in- eluding of leucopenia and thromboeytopenia,no patients dead for toxic reactions of chemotherapy. Conclusion ICE regimen was a safe and effective salvage regimen for the patients with relapsed and refractory NHL.
出处
《中国基层医药》
CAS
2011年第18期2479-2480,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
淋巴瘤
非霍奇
化学疗法
Lymphoma,non-Hodgkin
Chemotherapy
