摘要
目的观察小剂量环磷酰胺（CTX）治疗老年人系统性红斑狼疮（SLE）的疗效。方法选取初诊且未经治疗的老年SLE患者23例。予CTX每2周1次，3次后改为每4周1次，每次用量500mg，总量3g。泼尼松0．8mg·kg^-1·d^-1。于治疗前后对SLE患者进行SLE活动性指数（SLEDAI）评分，测定尿蛋白、血清补体、血清抗双链DNA抗体（ds-DNA）。结果共有19例患者随访至24周。治疗4周时与治疗前比较SLEDAI评分下降明显（P〈0．01），8周时继续下降（P〈0．05），治疗4周后尿蛋白量及补体与治疗前均有明显下降，ds．DNA明显下降。结论小剂量环磷酰胺联合标准剂量泼尼松对老年人系统性红斑狼疮的疗效明显，且不增加CTX的不良反应。
Objective To assess the efficacy of low-dose intravenous eyelophosphmide （IV CTX） in treat- ment of old patients with systemic lupus erythematosus（SLE）. Methods Twenty-three old patients with newly diag- nosed,untreated SLE were included. Patients received 3 times formighfly IV CTX pulses at a fixed dose of 400mg fol- lowed by 3 monthly pulses. All patients were orally administered 0.8mg/kg of prednisone. The changes of the indexes were observed before and after 12 weeks treatment including the scores of SLE disease activity index（SLEDAI） and the levels of C3, CA ,24-hour urinary protein and anti-dsDNA antibody. Results Among 23 patients, 19 were followed up to 24 weeks, SLEDAI 4 weeks after treatment were all significantly lower than those before the treatment （ P 〈 0. 01 ）. At week 8, SLEDAI continued to decrease （P 〈 0.05 ）. At week 4, the level of urine protein, the levels of com- plements C3 and CA and ds-DNA decreased significantly compared with that before the treatment （ P 〈 O. 05 ）. Conclusion Intensive low-dose CTX plus prednisone was effective in newly diagnosed, untreated old patients with SLE, and could reduce adverse effect.
出处
《中国基层医药》
CAS
2011年第20期2737-2738,共2页
Chinese Journal of Primary Medicine and Pharmacy
基金
广西壮族自治区卫生厅计划课题（Z2009044）
关键词
系统性红斑狼疮
环磷酰胺
老年人
Systemic lupus erythematosus
Cyclophosphamide
Aged
