摘要
目的:采用HPLC法测定螺内酯胶囊的含量。方法:色谱柱为Agilent C18(4.6 mm×250 mm,5μm),流动相为乙腈-水(50∶50),测定波长238 nm。结果:螺内酯在5.023 1～75.347 1μg间的线性良好(r=1),平均回收率为99.84%,RSD为0.33%。结论:该方法重现性好,操作简便,可用于螺内酯胶囊的质量控制。已被《中国药典》2010年版收载。
Objective： To establish an HPLC method for determination of Spironolactone Capsules. Methods： The stationary phase was Agilent C18 （ 4. 6 mm × 250 mm, 5 μm ） column and the mobile phase was acetonitrile-water （ 50 ： 50 ） at a wavelength of 238 nm. Results： Within 5.023 1 -75. 347 1 μg Spironolactone had a good linearity （r = 1 ） ,the average recovery was 99. 84% with RSD of 0. 33 %. Conclusion ：The method is reproducible, simple and can be used in the quality control of Spironolactone Tablets. The method shall be the legal method in Chinese pharmacopoeia 2010.
出处
《中国药品标准》
CAS
2011年第4期261-263,共3页
Drug Standards of China
