摘要
病毒、病毒感染的靶细胞和机体的抗病毒免疫是推动疾病进展的"三架马车",抗HBV治疗的"爬坡假说"根据宿主免疫应答的特点,提出调节宿主免疫应答的治疗策略可用以弥补单一抗病毒治疗慢性HBV感染的不足。笔者对病毒感染的免疫应答和免疫治疗研究的新进展进行综述。
Increasing evidence has shown that three critical elements - the HBV virion, the host＇s hepatocyte and immune sys- tems-engage in a dynamic interplay that drives the progression of HBV infection. Based on the characteristics of host immune response in patients with HBV infection, a ＂climbing slope hypothesis＂ is proposed to suggest that therapeutic strategies aiming at modulating the immune activity of the host may represent a complementary approach to antiviral drug treatment for the management of chronically HBV-infected patients. The review focuses on the progress of immune response and immune therapy in HBV-infected patients.
出处
《传染病信息》
2011年第4期193-198,共6页
Infectious Disease Information
基金
国家自然科学基金重点项目(30730088)
关键词
抗病毒治疗
疾病进展
乙型肝炎病毒
宿主免疫
免疫治疗
antiviral therapy
disease progression
hepatitis B virus
host immunity
immune therapy
