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100例尿毒症血液透析患者肝素诱导的血小板减少症发病率及临床特点 被引量：8

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摘要 目的探讨肝素诱导的血小板减少症（HIT）在尿毒症血液透析患者中的发病率及临床特点。方法选择2006年1月~2011年1月在本院首次行血液透析的尿毒症患者100例,均给予普通肝素体外抗凝治疗,每周血透3次,观察血小板计数及其他临床表现。结果 12例出现不同程度的血小板减少,4例（A组）HIT抗体阴性,8例（B、C组）HIT抗体阳性,这8例中4例伴有出血,2例出现下肢深静脉血栓,12例停用肝素改为无肝素透析后血小板计数均恢复正常,再次使用肝素后,A组血小板未明显下降,B、C组再次出现血小板计数减少,最终改为局部枸橼酸制剂为长期血透抗凝。结论尿毒症患者血透治疗使用肝素后发生血小板减少症并不少见,需警惕HIT可能,轻症患者可无明显临床表现,但部分患者会出现出血、栓塞等严重后果。
作者 黄馥菡 施向东
机构地区 湖州市中心医院
出处 《浙江实用医学》 2011年第4期259-261,共3页 Zhejiang Practical Medicine
关键词 肝素 肝素诱导的血小板减少症 尿毒症 血液透析
分类号 R459.5 [医药卫生—治疗学]
  • 相关文献

参考文献6

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二级参考文献8

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共引文献14

同被引文献48

  • 1胡大一,孙艺红.低分子肝素与血栓栓塞性疾病[J].中华心血管病杂志,2005,33(2):198-200. 被引量：37
  • 2程洪波,李国良,熊丽红,周桂秀,罗敏智,魏宇靖,王晓莉.影响血小板输注疗效的多因素分析[J].江西医学检验,2007,25(2):119-121. 被引量：9
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引证文献8

二级引证文献41

浙江实用医学
2011年 第4期

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