摘要
磷酸二酯酶超家族(PDEs)是细胞内重要的第二信使cAMP和cGMP的催化水解酶。该家族参与大量的生理学过程,包括心肌收缩、神经退行性病变、细胞凋亡、脂肪生成、糖原分解和糖异生作用等。因此,PDE具有成为多种疾病治疗靶点的潜力,包括抑郁、哮喘、炎症与勃起功能障碍等。现就磷酸二酯酶相关疾病的药理学进展作简单的综述。
Cyclic nucleotide phosphodiesterases（PDEs）,which are distributed in mammalian tissues,play an important role in cell signaling by hydrolyzing cAMP and cGMP.PDEs can selectively regulate various cellular functions such as myocardial contraction,neurodegeneration,apoptosis,lipogenesis,glycogenolysis and gluconeogenesis.Thus PDE has the potential to become target of the treatment for various diseases,including depression,asthma,inflammation and erectile dysfunction etc..Here is to make a brief review on the pharmacology of PDE related diseases.
出处
《医学综述》
2011年第18期2806-2808,共3页
Medical Recapitulate
